In 2001, Drs. Rainer Straub and Maurizio Cutolo, established experts in the field of neuroendocrine immunology of autoimmune and rheumatic diseases, published a large overview on the role of diverse neural and hormonal factors in rheumatoid arthritis.
In the last decade, Maurizio Cutolo, president of the European League against Rheumatism (EULAR) has also organized the first five international conferences on neuroendocrine immune basis of the rheumatic diseases.
In the May 2013 issue of Seminars in Arthritis and Rheumatism Drs. Straub and Cutolo, together with Drs. J. Bijlsma and A. Masi published a 10-year update on these issues.
Their focus was specifically on various aspects of the neuroendocrine-immune dysfunction in chronic musculoskeletal diseases. They review new fundamental and clinical data, accumulated over the last 10 years. Importantly, these experts summarize and group new evolving concepts in this field that may offer novel insights into the pathogenesis of rheumatic diseases.
According to the authors, these new concepts may provide the first therapies of chronic inflammatory diseases on the basis of neuroendocrine immune targets.
Source: Semin Arthritis Rheum, 2013 May 31. doi: 10.1016/j.semarthrit.2013.04.008. [Epub ahead of print]