Ozdolap S, et al. recently reported, at the European League against Rheumatism (EULAR) Annual European Congress of Rheumatology, June 10-13, 2015, a positive correlation between widespread pain and serum IL-8 in patients with fibromyalgia (FM).
Cytokines, depending on their concentration, induce symptoms, such as fatigue, fever, sleep, pain, and myalgia, all of which develop in FM patients. Until recently, no infectious or degenerative event that was responsible for the variation in these levels had been identified in FM patients, although factors, such as obesity, can cause these alterations.
Other reports have noted an association of high levels of IL-6 with painful events, surgical procedures and certain psychiatric disorders, as well as between fatigue and pain in animal models.
In the Ozdolap S, et al. study reported, at the EULAR Annual 2015 Congress forty-eight patients with fibromyalgia who met the American College of Rheumatology (ACR) 2010 criteria and 43 healthy women were enrolled. Widespread pain was evaluated using a Visual analog scale (VAS), the Widespread Pain Index (WPI) and the Symptom Severity Scale (SSS), and blood sera were analyzed for tumor necrosis factor-alpha (TNF-a), interleukin (IL)-1-beta, IL-8 and oxidized low-density lipoprotein (LDL).
Although no overall differences in TNF-alpha, IL-1-beta, IL-8and oxidized LDL were seen between the groups, a relationship with VAS and serum IL-8 and TNF-a were observed in the patient group.
The work of Ozdolap S, et al. substantiates previous work indicating that the pro-inflammatory chemokine IL-8 may contribute to the pathogenesis of fibromyalgia (Wang H. et al., 2009). In this study, before and during the inpatient therapy, the serum level of IL-8 was significantly higher in patients with FM compared with controls but did not correlated with pain intensity and medication.
In 2018, the groupd of Şenay ÖZDOLAP published in Archives of Rheumatology a full research article, entitled: ‘Pro-inflammatory Cytokines and Oxidized Low-Density-Lipoprotein in Patients With Fibromyalgia’. In this article Funda Canpolat KUTU, Şenay ÖZDOLAP, and Selda SARIKAYA report that there was no difference in levels of the serum TNF-α, IL-1β, IL-8, and Ox-LDL between FM patients and healthy controls.