If you are passionately interested and hooked to inter-disciplinary and integrative medical research, take a look below at our selection of the Top 10 Brainimmune Updates. And perhaps why these stories may be fundamentally and clinically important.
From 2011 we started to publish short news and what’s hot or blog stories, with the idea to spread the word about some innovative and advanced research in the field. The selected updates are from these sections.
As some of these stories were published more than 10 years ago, naturally the question of bringing updates was raised for discussion. The time frame and recent Google SEO-related demands convinced us that we should proceed. Strictly scientifically, we wanted to find out if a story and research concept written and developed 10 years ago is still relevant nowadays.
And last but not least,
are these stories still fundamentally and clinically important today?
First, most of these stories reflect an innovative, advanced, stimulating etc. research, niche, or conceptual framework of the new and rapidly developing inter-disciplinary area of neuroendocrine-immunology and stress-immune interactions. Second, you will find for yourself several reasons these stories to be included here – in the discussion section(s) of the articles. And third, we will provide, and make an attempt to highlight some of the most important fundamental and clinical implications.
Thus, here’s a look at our selection of the Top 10 Brainimmune Updates:
Major story – a PNAS article indicating that Chlamydophila pneumoniae phospholipase D (CpPLD) is a major C. pneumoniae factor able to induce T helper 17 (Th17) cells’ immune response in atherosclerosis.
Figure with the summary of the putative protective and pathogenic effects of IL-17 in atherosclerosis. From: IL-17 and Th17 Cells in Atherosclerosis by S. Taleb, A. Tedgui and Z. Mallat; Arterioscler Thromb Vasc Biol, 2015 Feb;35(2):258-64. Public domain.
Perhaps the first study to suggest that CpPLD is driving Th17 inflammation within the atherosclerotic plaque, and that the CpPLD-related Th17 pathway may represent a new therapeutic target for the prevention and/or treatment of atherosclerosis.
Major story – a Science magazine article providing evidence that autonomic nerves contribute to prostate cancer development, where the sympathetic nervous system via the activation of β2 and β3-adrenergic receptor pathways participate in the early phase of tumor development.
The authors conclude that autonomic nerves infiltrate the prostatic tumor, and sympathetic/noradrenergic fibers are implicated in the initial stages of tumor development. The study sheds light on the exciting potential of using already available and widely used therapeutics such as beta-blockersto impact cancer prognosis.
Major story – a PNAS article demonstrates that a cool ambient housing temperature may affect the outcome of a broad range of experimental endpoints, including antitumor immunity and experimental tumor growth in mice.
Several studies indicating that chronic psychosocial stress in mice not only increases the number of myeloid-derived suppressor cells (MDSC) and Treg cells, but in the case of MDSC, also enhances their suppressive capacity.
According to a report and survey published in Psychooncology a substantial part of women who had survived breast cancer believe that there is a link between breast cancer and psychological stress. As per another, 2018 study discussed here – salient Life Events (LEs) differentially influence breast cancer risk according to stress perception – negative valence, cumulative LEs perceived as stressful seem to be most influential in increasing breast cancer risk.
NEUROENDOCRINE IMMUNOLOGY OF AUTOIMMUNITY & CHRONIC INFLAMMATION
Major story – a European Journal of Immunology article linking chronic stress and autoimmunity through a mechanism referred to as glucocorticoid resistance. This is also substantiated by a 2012 study, discussed here, indicating that chronic stress may induce glucocorticoid receptor resistance (GCR), which in turn, interferes with appropriate regulation of inﬂammation.
Major story – a study published in the June 05, 2014 issue of Nature magazine indicates that sensory nerves driving interleukin-23 (IL-23) production by dermal dendritic cells (DDCs) may contribute to psoriasis-like inflammation. These findings may represent a breakthrough in psoriasis research and the understanding of the pathogenesis of this skin disease.
Major story – a study published in the Proceedings of the National Academy of Sciences of the USA (PNAS) is perhaps the first to demonstrate that the magnitude of peripheral interleukin (IL)-6 responses preceding stress challenge may confer inter-individual differences in susceptibility or resilience to a subsequent social stressor.
The authors conclude that individual differences in the sensitivity of some peripheral immune cells, and more specifically, their IL-6 hyper-responsiveness are pre-existing and may determine a greater risk of developing a stress-related disorder, such as depression in a subgroup of susceptible individuals.
Major story – A study published in the Journal of Psychiatric Research extends the results of two previous studies and provides evidence for a deficit of oxytocin in women with depression, including patients with psychotic major depression (PMD), who typically exhibit greater depressive severity.