Abstract Psychological stress plays a role in the pathogenesis of several autoimmune disorders. In this overview, we will describe our...
Fundamentals
Fundamental aspects of brain-immune interactions
Acid Sensing – Sensory Neurons – Inflammation – BrainImmune Chronic inflammatory conditions, such as rheumatoid arthritis (RA), are characterized by...
The purinergic signaling system, also known as a ‘purinome’, represents extracellular signaling cascades, which are mediated by Adenosine Triphosphate (ATP)...
Sex Hormones and Immunoregulation The sexual dimorphism in immune responses in humans is well known; females have more vigorous cellular...
Brain-Immune Signaling and Pathogen Recognition The body’s reaction to infections involves the orchestration of multiple systems to effectively initiate, execute...
The immune and nervous systems are anatomically and functionally interconnected, this cross-talk is evidenced by the dense innervation – mainly...
Brain TNF and Chronic Pain – BrainImmune We have determined that enhanced expression of the pro-inflammatory cytokine Tumor Necrosis Factor...
Endogenous catecholamines in immune cells – BrainImmune The catecholamines dopamine, noradrenaline and adrenaline are well established neurotransmitters and neurohormones. Sympathoadrenergic...
T Cell – Antigen Presenting Cell – Sleep Sleep supports immune defense. In the first half of nocturnal sleep, slow...
Interferon and CNS Interferons (IFNs) are glycoproteins known as cytokines. These cytokines got their name by Isaacs and Lindenmann [1]...
Sympathetic Nervous System – Regulatory T cells Homeostatic control of the immune system is dependent on CD4, FoxP3+, NKT or...
The nervous and immune systems share common functions: both are involved in adapting the body to the environment and in...