Acid Sensing – Sensory Neurons – Inflammation – BrainImmune Chronic inflammatory conditions, such as rheumatoid arthritis (RA), are characterized by...
Fundamentals
Fundamental aspects of brain-immune interactions
Nervous system control – leukocyte distribution Leukocytes are key components of the body’s defense system and the major subsets of...
Brain TNF and Chronic Pain – BrainImmune We have determined that enhanced expression of the pro-inflammatory cytokine Tumor Necrosis Factor...
Endogenous catecholamines in immune cells – BrainImmune The catecholamines dopamine, noradrenaline and adrenaline are well established neurotransmitters and neurohormones. Sympathoadrenergic...
The immune and nervous systems are anatomically and functionally interconnected, this cross-talk is evidenced by the dense innervation – mainly...
The nervous and immune systems share common functions: both are involved in adapting the body to the environment and in...
The purinergic signaling system, also known as a ‘purinome’, represents extracellular signaling cascades, which are mediated by Adenosine Triphosphate (ATP)...
Brain-Immune Signaling and Pathogen Recognition The body’s reaction to infections involves the orchestration of multiple systems to effectively initiate, execute...
Abstract Psychological stress plays a role in the pathogenesis of several autoimmune disorders. In this overview, we will describe our...
Sympathetic Nervous System – Regulatory T cells Homeostatic control of the immune system is dependent on CD4, FoxP3+, NKT or...
Interferon and CNS Interferons (IFNs) are glycoproteins known as cytokines. These cytokines got their name by Isaacs and Lindenmann [1]...
Regulation T Helper Cell – Extracellular ATP During immune responses a tight balance between proinflammatory and regulatory mechanisms is key...