According to a study published in the journal Pediatrics, a research team from Denmark provides new evidence that the offspring of women who deliver by cesarean section may have an increased risk for certain immune-related diseases.
Recently the American College of Obstetricians and the Society for Maternal-Fetal Medicinereleased new guidelines, relevant mostly for first-time mothers that are aimed at safe prevention of the primary cesarean delivery.
In the Pediatrics study, Astrid Sevelsted and colleagues from the University of Copenhagen & the Danish Pediatric Asthma Center, Copenhagen University Hospital, Copenhagen, Denmark collected data from 2 million full-term children born by cesarean section, as recorded in the Danish national registries between 1977 and 2012.
The authors of this study report that children delivered by cesarean section had significantly increased risk of asthma, systemic connective tissue disorders, juvenile arthritis, inflammatory bowel disease, immune deficiencies and leukemia.
The study support the hypothesis that the perinatal life is important for later development of chronic diseases.
Sevelsted et al. discuss that the normal delivery canal exposes the child to a composite microbiome different from the one encountered during a cesarean delivery. Thus, the effect from cesarean delivery is mediated by “changes in the microbiome of the newborn”.
This includes “1) acquisition of an atypical microbiome at birth; 2) the effect of labor on the immune system; and 3) the development of memory of the first two events through epigenetic changes that modify the nature of the immune response and predispose to immune-related disorders” (after cesarean section).