Pro-Inflammatory Th17 Cells Glucocorticoid Resistance

Pro-Inflammatory Th17 Cells and Glucocorticoid Resistance: Implications for Chronic Inflammatory Diseases and Their Treatment

Stress-Induced Th2 Shift Thyroid Autoimmunity

Stress-Induced Th2 Shift and Thyroid Autoimmunity: A Unifying Hypothesis

How Stress Prevents Immunostimulatory Effects Interleukin-12

How Stress Prevents the Immunostimulatory Effects of Interleukin-12

Sympathetic Nervous System: Regulator of Breast Cancer Metastasis

NEWS

The Top 10 BrainImmune Updates and Why These Stories Are Fundamentally and Clinically Important

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Neuroendocrine Phenotypes that Affect Immune Responses in Mammals Found in Avian Species

Beta-adrenoceptor Activation Reduces Host Viral Resistance by Preventing IFN-γ Production in Liver NK Cells

Role of Peripheral Immunity in Cognitive Decline During Parkinson’s Disease

Learned Immunosuppressive Placebo Responses Attenuate Disease Progression in a Rat Model of Arthritis

FEATURED

Beta-Blockers Propranolol Beneficial Breast Cancer

Beta-Blockers Emerge as Beneficial in Early and Triple-Negative Breast Cancer: Reasons Why and the Role of a Sympathetic Overdrive in TNBC Patients

Evidence accumulated over the last 20 years indicates that beta-blockers are beneficial or perhaps even life-saving in early stage breast cancer (BC). Importantly, beta-blockers reduce mortality and have a more pronounced prognostic effect mainly in triple-negative breast cancer...

WHAT'S HOT

The Top Ten Most-Read Brainimmune Stories of 2022

Encouraging Results Oral Antiviral Molnupiravir

Encouraging Results from Phase 2a COVID-19 Clinical Trial with the Oral Direct-Acting Antiviral Molnupiravir

US Antiviral Program for Pandemics

Platelet-activating anti-PF4 antibodies linked to the vaccine-induced immune thrombotic thrombocytopenia

Identification of GM-SCF as possible distinctive blood marker predicting severe COVID-19

COVID-19 and Cardiovascular Diseases Surge

EDITORIALS & OPINION | COMMENTARIES

Brain Lymphatics and Neuronal Homeostasis

The IL-6 Inhibitors Tocilizumab and Sarilumab and COVID-19 Treatment: Controversies but Potential Efficacy in Severe Cases

The Brain Glymphatic System: From a Good Night’s Sleep to the Onset of Dementia

New Evidence for Key Factors that Drive COVID-19 Severity

Stress, Dyshomeostasis and COVID-19 Mortality: A Big Picture View

EVOLVING CONCEPTS

Timing is everything Novel Combinatorial Approaches Overcome Immunosuppression

Timing is everything: Novel Combinatorial Approaches to Overcome the Immunosuppression in Prostate Cancer

The Emerging Role of Neuro-Immune Synapses and the Immunological Homunculus in the Context of the Systematic Lymphoid Organs Innervation

Microglia: gatekeepers for neuropathic pain

The Cross-talk between the Dopaminergic System and Innate Immunity: An Evolving Concept

An Evolving Concept: The Pathologic Level of Brain TNF is a Therapeutic Target for Chronic Pain Treatment

STRESS & IMMUNITY

Stress & Organ Specific Autoimmunity: A Complex Interrelationship

Psychosocial Stress and Chronic Viral Hepatitis

Stress and Cancer: A Link Through the Chinese Cultural Revolution

The Link Between Stress, Emotions and Cytokine-Related Diseases

Pro- and Anti-Inflammatory Effects of Stress in the Brain: Mechanisms and Implications

FUNDAMENTALS

Disruption of Brain TNF Homeostasis Elicits Maladaptive Alterations Producing Chronic Pain

Acid Sensing By Sensory Neurons in Inflammation

Acid Sensing – Sensory Neurons – Inflammation – BrainImmune Chronic inflammatory conditions, such as rheumatoid arthritis (RA), are characterized by continuous pain and RA is the most frequent form of inflammatory joint disease in the...

Endogenous Catecholamines in Immune Cells: Discovery, Functions And Clinical Potential as Therapeutic Targets

Endogenous catecholamines in immune cells – BrainImmune The catecholamines dopamine, noradrenaline and adrenaline are well established neurotransmitters and neurohormones. Sympathoadrenergic pathways are pivotal to the communication between the nervous system and the immune system, and...

CLINICAL OVERVIEWS

Sex Steroids Hormones and Autoimmune Disease Activity

Sex Steroids and Autoimmune Disease – BrainImmune Females display an increased incidence of autoimmune diseases, with a sexual dimorphism in the immune response. The autoimmune diseases involve both genetic and...

Neuroendocrine-Immune Interactions in Lung Inflammatory Diseases

Inflammation is the body’s response to insults. During inflammation, various inflammatory cells are activated to release cytokines and mediators and orchestrate progressing inflammation. Clinically, pneumonia and acute respiratory distress syndrome...

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