Th17 and Th22 Cells May Contribute To the Pathogenesis of Guillain-Barré Syndrome

Th17 and Th22 Cells May Contribute To the Pathogenesis of Guillain-Barré Syndrome

A study by Shujuan Li and colleagues from the Jilin University, Changchun, China, suggests that Th17 and Th22 cells might be involved in the onset and development of Guillain-Barré Syndrome.

T helper (Th)17 cells and the interleukin (IL)-23→IL-17 axis drive chronic inflammation in many autoimmune diseases.

The report by Li et al, published in the journal Mediators of Inflammation, indicates that in the early, acute phase of Guillain-Barré syndrome circulating Th17, Th22 cells and Th1 cells are increased along with the plasma levels of IL-17 and IL-22.

This may also indicate that targeting Th17 and Th22 cells may have therapeutic potential in Guillain-Barré syndrome. In fact, a more recent review published in Expert Opinion on Therapeutic Targets provides a more detailed discussion along these lines.

Source: Mediators Inflamm, 2014:740947. doi: 10.1155/2014/740947. Epub 2014 May 12.
Read More: Mediators of Inflammation

Source: Cover Image: Th17 Cells - A New T Cell Lineage, http://www.ebioscience.com/knowledge-center/cell-type/th17-cells.htm Public domain; Credit: ebioscience.com http://www.ebioscience.com/

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