vagus nerve

The Central Inflammatory Reflex: Afferent Vagal and Central Brain Stimulations Control Experimental Arthritis

The Central Inflammatory Reflex: Afferent Vagal and Central Brain Stimulations Control Experimental Arthritis

PhD THESIS SYNOPSIS Inflammation is a protective and complex biological response to harmful stimuli, such as infection and tissue damage, that involves cell infiltration and production of inflammatory cytokines. Rheumatoid Arthritis (RA) is the most common type of inflammatory autoimmune disease affecting over 1.5 million adult Americans. It is characterized by chronic inflammation of synovial […]

Activation of the Brain-Splenic Nerve Axis in Hypertension: The Cholinergic-Sympathetic-Immune System Connection

Activation of the Brain-Splenic Nerve Axis in Hypertension: The Cholinergic-Sympathetic-Immune System Connection

A recent Nature Communications study indicates that hypertension is linked to T cell activation and an egression of T-cells from the spleen, and that this process is dependent on a vagus-splenic nerve connection. Hypertension is a major risk factor for coronary heart diseases and stroke. Despite various therapeutic approaches 10-15% of the general hypertensive population […]

Therapeutic Potential of α7 Nicotinic Acetylcholine Receptor Agonists in a Murine Model of Rheumatoid Arthritis

Therapeutic Potential of α7 Nicotinic Acetylcholine Receptor Agonists in a Murine Model of Rheumatoid Arthritis

According to van Maanen et al., and their recent publication in PLoS One, two new experimental compounds affecting the acetylcholine-receptor system are able to delay collagen-induced arthritis (CIA) in mice, showing the therapeutic potential of chemicals targeting the α7 subunit of nicotinic acetylcholine receptors (α7nAChR). Previous research revealed that the efferent vagus nerve may decrease […]

Vagus Nerve Stimulation Ameliorates Disease Activity in a Rodent Model of Rheumatoid Arthritis

Vagus Nerve Stimulation Ameliorates Disease Activity in a Rodent Model of Rheumatoid Arthritis

A study published in PLoS ONE is perhaps the first to demonstrate that electrical neurostimulation of the vagus nerve reduces signs of inflammation and disease severity in the collagen-induced arthritis (CIA), a disease model of rheumatoid arthritis in rodents. Previous research indicates that cholinergic signaling along the vagus nerve is able to affect the production […]

Evidence that electroacupuncture affects immunity through a specific dopaminergic neuroendocrine pathway

Evidence that electroacupuncture affects immunity through a specific dopaminergic neuroendocrine pathway

A new study, published in the February 23, 2014 issue of Nature Medicine (Advance Online Publication) provides perhaps the first robust evidence that acupuncture’s effects are translated through specific neuroendocrine and immune pathways. The way acupuncture affects human physiologic processes, and particularly immune function and homeostasis, is not well understood. Acupuncture has always been considered […]

Role of the Vagus Nerve at the Neural-Immune Interface

Role of the Vagus Nerve at the Neural-Immune Interface

Overview article Evidence shows that the central nervous system monitors and modulates the activity of both circulating and tissue immune cells via the neuroendocrine system and autonomic nerves. Furthermore, findings over the last decade have demonstrated that the vagus nerve represents an important bi-directional link between the brain and immune system. Afferent vagal pathways transmit […]