vagus nerve stimulation

Afferent Vagus Nerve Stimulation Activates Brain Locus Coeruleus and Improves Experimental Joint Inflammation

Afferent Vagus Nerve Stimulation Activates Brain Locus Coeruleus and Improves Experimental Joint Inflammation

A recent study published in the Brain, Behavior, and Immunity journal indicates, for the first time, that stimulation of vagal afferents or specific brain areas can modulate joint inflammation. This new central pathway involves sympathetic nervous system activation and local stimulation of synovial β-adrenoceptors. Vagus nerve stimulation (VNS) is a well-known procedure that limits inflammation and […]

The Central Inflammatory Reflex: Afferent Vagal and Central Brain Stimulations Control Experimental Arthritis

The Central Inflammatory Reflex: Afferent Vagal and Central Brain Stimulations Control Experimental Arthritis

PhD THESIS SYNOPSIS Inflammation is a protective and complex biological response to harmful stimuli, such as infection and tissue damage, that involves cell infiltration and production of inflammatory cytokines. Rheumatoid Arthritis (RA) is the most common type of inflammatory autoimmune disease affecting over 1.5 million adult Americans. It is characterized by chronic inflammation of synovial […]

Vagus Nerve Stimulation Ameliorates Disease Activity in a Rodent Model of Rheumatoid Arthritis

Vagus Nerve Stimulation Ameliorates Disease Activity in a Rodent Model of Rheumatoid Arthritis

A study published in PLoS ONE is perhaps the first to demonstrate that electrical neurostimulation of the vagus nerve reduces signs of inflammation and disease severity in the collagen-induced arthritis (CIA), a disease model of rheumatoid arthritis in rodents. Previous research indicates that cholinergic signaling along the vagus nerve is able to affect the production […]