Th17

Important New Features and Glucocorticoid-Resistance of Pro-Inflammatory Th17 Cells

Important New Features and Glucocorticoid-Resistance of Pro-Inflammatory Th17 Cells

A recent study by Radha Ramesh and colleagues, published in the Journal of Experimental Medicine indicates that the expression of the multi-drug transporter MDR1 (also known as P-glycoprotein [P-gp] and ABCB1) is a marker that defines the pro-inflammatory nature of T helper (Th)17 cells. The Th17 cells are major players in inflammatory/autoimmune conditions, but not […]

First Evidence That Th22 Cells May Contribute To the Pathogenesis of Graves’ Disease

First Evidence That Th22 Cells May Contribute To the Pathogenesis of Graves’ Disease

COMMENTARY ARTICLE on the study by Di Peng et al., PLoS One. 2013 Jul 11;8(7):e68446 A High Frequency of Circulating Th22 and Th17 Cells in Patients with New Onset Graves’ Disease The many immune mechanisms involved in the onset and development of autoimmune diseases make their pathophysiology heterogeneous and complex. Among them, CD4+ T cells […]

Reproduction and Fertility Linked to the Estradiol’s Regulation of NF-κb Translocation in Dendritic Cells

Reproduction and Fertility Linked to the Estradiol’s Regulation of NF-κb Translocation in Dendritic Cells

A new study published in Genes & Immunity may explain why some immune responses, and particularly dendritic cells (DCs) functions are restrained during ovulation. The menstrual cycle is related to subtle changes in sex hormone levels (see Cover Image) that may have, however, profound effects on innate and adaptive immune responses. Estradiol levels, which are […]

Sperm-Induced Th17 Immune Responses and Their Control by Sex Hormones: Implications for Fertility

Sperm-Induced Th17 Immune Responses and Their Control by Sex Hormones: Implications for Fertility

A new study by Miguel Relloso and colleagues from the Hospital General Universitario Gregorio Marañón in Madrid, Spain, identifies the female sex hormones as important regulators of the T helper (Th)17 response induced by sperm, and related to dendritic cells (DCs), the key professional antigen-presenting cells. Sperm is a foreign antigen (material) and its contact […]

First Report That Interleukin-17A Levels Are Increased In Fibromyalgia Patients

First Report That Interleukin-17A Levels Are Increased In Fibromyalgia Patients

A recent study by Andrei Pernambuco and colleagues from the Federal University of Minas Gerais, Belo Horizonte, MG, Brazil is perhaps the first to document increased plas­ma levels of interleukin (IL)-17A in fibromyalgia (FM) patients. Interleukin-17 and the T helper (Th)-17 cells play a key role in tissue inflammation and host defense and, recently, the […]

Chronic Variable Stress May Promote Autoimmunity through Induction of Glucocorticoid Resistance

Chronic Variable Stress May Promote Autoimmunity through Induction of Glucocorticoid Resistance

A new European Journal of Immunology study links chronic stress and autoimmunity through a mechanism referred to as glucocorticoid resistance. The effect of psychological stress on autoimmunity is extremely complex, at multiple levels, and can be in either direction. Often, stress is related to both induction/exacerbation and amelioration of disease activity. Stress hormones selectively suppress […]

Leptin Induces Th17 Responses: Relevance to Systemic Lupus Erythematosus

Leptin Induces Th17 Responses: Relevance to Systemic Lupus Erythematosus

A new Cutting Edge article, in the April 2013 issue of the Journal of Immunology, identifies a link between leptin and T helper (Th)17 cells, based on the evidence that leptin was able to promote Th17 responses in human CD4+ T cells and in mice, both in vitro and in vivo, by inducing the transcription […]

Activation of Beta2-Adrenoreceptors Drives T Helper Cell Priming In Favor of IL-17 Responses

Activation of Beta2-Adrenoreceptors Drives T Helper Cell Priming In Favor of IL-17 Responses

In a recent study published in the journal Cytokine, Michela Manni, Richard Granstein and Georges Maestroni, from the Center for Experimental Pathology, Locarno, Switzerland, provide new evidence suggesting that catecholamines, through activation of beta2-adrenoreceptors (ARs) on immune cells, may drive, in certain conditions, Th17 immune responses. The authors report that the beta2-AR agonist salbutamol is […]

Microbial Deprivation, Inflammation and the Th17/IL-23 Axis in Cancer Development

Microbial Deprivation, Inflammation and the Th17/IL-23 Axis in Cancer Development

In a recent review article in Cancer and Metastasis Reviews Leena von Hertzen, H. Joensuu and T. Haahtela, from the Skin and Allergy Hospital, Helsinki University Central Hospital, Finland, summarize the epidemiological data related to microbe-rich environments and cancer, and discuss the involvement of the T helper (Th)17/Interleukin(IL)-23 axis and the immunomodulatory potential of environmental microbiota […]

1,25-Dihydroxyvitamin D3 Transcriptional Repression of Interleukin-17A Expression and Th17-Related Autoimmunity

1,25-Dihydroxyvitamin D3 Transcriptional Repression of Interleukin-17A Expression and Th17-Related Autoimmunity

In a new Molecular and Cellular Biology study, Sneha Joshi and colleagues from the University of Medicine and Dentistry of New Jersey, Newark demonstrate that the reversal of paralysis in EAE mice by 1,25-Dihydroxyvitamin D3 correlates with reduced IL-17A-secreting CD4+ T cells, and that the mechanism involved in 1,25-Dihydroxyvitamin D3-mediated suppression of IL-17A induction involves […]

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