stress and disease

Stress, Proinflammation, Autoregulation and Cardiovascular Diseases

Stress, Proinflammation, Autoregulation and Cardiovascular Diseases

OVERVIEW ARTICLE Chronic stress can be an extremely detrimental phenomenon because it maintains an artificial state of excitation, whereas acute stress ends this process in a more timely manner. Therefore, it is not surprising to find proinflammatory phenomena occurring during chronic stress since the system maintains excitability, including that of immune origin. The cardiovascular system […]

Stress Response in Childhood Asthma

Stress Response in Childhood Asthma

OVERVIEW ARTICLE Accumulated evidence from animal models suggests that exogenously applied stress enhances airway reactivity and increases airway inflammation. This is considered to be the result of their inability to increase glucocorticoid production in response to stress to suppress the immune reaction. Clinical observations that stressful life events in asthmatic subjects increase the risk of […]

Mental State and Tuberculosis – Tohru Ishigami, 1918

Mental State and Tuberculosis – Tohru Ishigami, 1918

HISTORY OVERVIEWS Tohru Ishigami was born in 1857, in the midst of a tempestuous period in Japanese history. The American fleet led by commodore Perry had arrived in Yokohama in 1853, and Japan slowly began to veer away from its isolationist policies, opening up to a flood of Western influence in various arenas. Importantly, transfer […]

Hans Selye and the Birth of the Stress Concept

Hans Selye and the Birth of the Stress Concept

HISTORY OVERVIEWS In 1936 a half page report appeared in Nature magazine under the title “A syndrome produced by diverse nocuous agents,” which was authored by Hans Selye of McGill University, Montreal, Canada [1]. The essence of this report was that rats exposed to a variety of nocuous or toxic agents (e.g. cold, surgery, forced […]

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