stress and disease

The Stress(ed) World and Hans Selye

The Stress(ed) World and Hans Selye

SHORT FEATURES and FACES ARTICLE 80 years after Hans Selye introduced the concept and term ‘stress’ there is a very substantial body of evidence that psychological stress is linked to the pathogenesis of several common human diseases. According to the American Institute of Stress, stress is America’s #1 health problem. Two-thirds of all office visits […]

George P. Chrousos – 30 years of Stress Research

George P. Chrousos – 30 years of Stress Research

SHORT FEATURES and FACES ARTICLE George P. Chrousos is professor and chairman of the Department of Pediatrics at the Athens University Medical School, and Distinguished Visiting Scientist, National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, Maryland. He was for many years Section Chief, and later Branch Chief of the Pediatric and Reproductive […]

The Stress-Susceptible Individual and the Risk for Inflammatory Diseases

The Stress-Susceptible Individual and the Risk for Inflammatory Diseases

SHORT FEATURES and FACES ARTICLE In this recent editorial Gailen Marshall, Editor-in-Chief of Annals of Allergy, Asthma & Immunology, discusses the topic of identifying and stratifying stress-susceptible individuals and established patients, and the relevance of correlating this susceptibility to the presence and/or progression of immune-mediated inflammatory conditions. An increasing body of evidence suggests stress is […]

Stress and Rheumatic Diseases

Stress and Rheumatic Diseases

SHORT FEATURES and FACES ARTICLE In this editorial Afton Hassett and Daniel Clauw, of University of Michigan Medical School, discuss some aspects of the complex interactions between psychological stress and the onset, expression and progression of rheumatic diseases. The authors mention that some studies in this research area are limited by the use of cross-sectional […]

Stress: From Hans Selye to Paris Hilton

Stress: From Hans Selye to Paris Hilton

SHORT FEATURES and FACES ARTICLE In this editorial, Gerald Weissmann comments on the modern use of the word “stress” and its evolution from Hans Selye’s original definition. According to Weissmann, Selye first advanced the notion of stress as a generalized response to any insult in 1936, which ultimately led to the investigation of stress hormones […]

A Combination of Beta-Adrenergic Antagonist and Cyclooxygenase-2 Inhibitor Improves Survival Rates in Murine Models of Postoperative Metastasis

A Combination of Beta-Adrenergic Antagonist and Cyclooxygenase-2 Inhibitor Improves Survival Rates in Murine Models of Postoperative Metastasis

A study published in the Journal of Immunology suggests that the combined blockade of excess release of catecholamines (CAs) and prostaglandins (PGs) in cancer patients undergoing tumor excision might improve survival rates and prevent cancer recurrence. The surgical procedure, a common step in the treatment of most solid cancers, has long been suspected to facilitate […]

Substance P Promotes Th17 Phenotype in Generalized Anxiety Disorder

Substance P Promotes Th17 Phenotype in Generalized Anxiety Disorder

A study published in the journal of Clinical Immunology demonstrates that the cytokine profiles in generalized anxiety disorder (GAD) individuals show traits of Th1 and Th2 deficiencies but are associated with a predominant Th17 phenotype, particularly in the presence of substance P (SP). Substance P has been shown to stimulate the inflammatory response, contributing to […]

Pro- and Anti-Inflammatory Effects of Stress in the Brain: Mechanisms and Implications

Pro- and Anti-Inflammatory Effects of Stress in the Brain: Mechanisms and Implications

OVERVIEW ARTICLE Some stress protocols show a pro-inflammatory response in the brain and other systems characterized by a complex release of several inflammatory mediators such as cytokines, transcription factors, prostanoids and free radicals. Such response might contribute to cell damage during several neuropsychiatric diseases related with stress (post-traumatic stress disorder, major depressive disorder, anxiety disorders, […]

Childhood Roots of Health Disparities

Childhood Roots of Health Disparities

Recently, in JAMA, Jack Shonkoff, W. Thomas Boyce and Bruce McEwen discussed a new way of thinking about health promotion and disease prevention. Adult conditions such as coronary heart disease, stroke, diabetes, and cancer are often regarded solely as products of adult behavior and lifestyles. But in the JAMA review the authors outline a new […]

Stress and Disorders of the Stress System

Stress and Disorders of the Stress System

A recent article published in Nature Reviews Endocrinology provides a brief but comprehensive overview on the conceptual evolution, and current understanding of homeostasis and the pathogenic disturbances that are associated with stress and the disorders of the stress system. Homeostasis, a term coined by the American physiologist Walter Cannon in the beginning of the 20th […]

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