stress and disease

Richard Kvetnansky – 45 years of Stress Research

Richard Kvetnansky – 45 years of Stress Research

SHORT FEATURES and FACES ARTICLE Richard Kvetnansky, M.D., is the head of the Laboratory of Stress Research at the Institute of Experimental Endocrinology, Slovak Academy of Sciences in Bratislava, Slovakia. He was a director of the Institute for eight years. Dr. Kvetnansky, an experimental endocrinologist, has performed seminal work in the field of the sympathoadrenal […]

Psychosocial Stress and Chronic Viral Hepatitis

Psychosocial Stress and Chronic Viral Hepatitis

OVERVIEW ARTICLE Psychological stress is defined as a “state in which homeostasis is actually threatened or perceived to be so”, whereas homeostasis represents the complex and dynamic equilibrium between all systems functioning in a living organism [1, 2]. The above definition and context excludes psychiatric disorders that may impair the integrative capacities of the individual. […]

First Evidence That Psychological Stress Alters Levels Of Suppressor Cells in Breast Cancer

First Evidence That Psychological Stress Alters Levels Of Suppressor Cells in Breast Cancer

A new study in Cellular Immunology is perhaps the first to specifically measure levels of myeloid-derived suppressor cells (MDSC) in post operative breast cancer patients who were considered to be macroscopically disease-free. In this study, Bethany Mundy-Bosse and colleagues from the Department of Integrated Biomedical Sciences, the Ohio State University, Columbus OH investigated the association […]

Effect of Catecholamines on Bacterial Growth: New Mechanism of Stress Influencing Digestive Health and Disease

Effect of Catecholamines on Bacterial Growth: New Mechanism of Stress Influencing Digestive Health and Disease

In a contemporary review, published in Cell and Tissue Research, Mark Lyte, Lucy Vulchanova and David Brown provide a brief but comprehensive overview of the actions of stress mediators, especially CAs, on enteric luminal bacteria, on gut mucosal interactions with bacteria, and on brain–gut interactions initiated by or influencing enteric bacteria. The autonomic nervous system […]

Stress and Cancer: A Link Through the Chinese Cultural Revolution

Stress and Cancer: A Link Through the Chinese Cultural Revolution

OVERVIEW ARTICLE It is now well recognized that preventive health care requires going beyond the immediate causes of diseases and understanding their fundamental socio-economic determinants. Cancer is one of these diseases that has emerged as the top killer, both physically and economically, surpassing heart disease, in many high-income countries. Does stress contribute to these increasing […]

Glucocorticoid Receptor Resistance Linked to Inflammation and Increased Disease Risk

Glucocorticoid Receptor Resistance Linked to Inflammation and Increased Disease Risk

A new Proceedings of the National Academy of Sciences of the USA (PNAS) study suggests that prolonged stress results in glucocorticoid receptor resistance (GCR), which results in a dysfunctional stress-immunity interaction, and, in turn, interferes with appropriate regulation of inflammation. The hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic-adrenomedullary system are the two major peripheral components of […]

Pathways by Which Stress May Affect Pregnancy Outcomes, Maternal Health and Fetal Development

Pathways by Which Stress May Affect Pregnancy Outcomes, Maternal Health and Fetal Development

In a recent review article in the journal Neuroscience & Biobehavioral Reviews, Lisa Christian discusses some biological mechanisms linking stress with maternal health, pregnancy outcomes and fetal development, focusing on peripheral immune markers, and stress reactivity and inflammatory processes during pregnancy Preterm delivery affects 12–13% of birth in the US, versus 5–9% in other developed […]

Psychological Stress and Cardiovascular Diseases: Overview of Clinical & Epidemiological Data

Psychological Stress and Cardiovascular Diseases: Overview of Clinical & Epidemiological Data

A review published in Postgraduate Medicine provides a comprehensive overview of the growing pool of clinical and epidemiological data concerning the association between psychological stress and cardiovascular disease, as well as the impact of cardiac rehabilitation and exercise therapy on psychological stress-related cardiovascular events. “Stress” is one of the most common patient complaints and up […]

Psychological Stress, Immunoregulatory Balance and Human Inflammatory Diseases

Psychological Stress, Immunoregulatory Balance and Human Inflammatory Diseases

A recent review published in the journal Immunology and Allergy Clinics of North America provides a brief but comprehensive overview of the major immune mechanisms affected by stress, and the relationships linking stress with various inflammatory diseases. In this review, Gailen Marshall from the University of Mississippi Medical Center outlines recent data indicating that immunoregulatory […]

Bungee Jumping Related Stress Response May Suppress Innate Immunity Through the Activation of a Noncanonical Glucocorticoid Signaling Pathway

Bungee Jumping Related Stress Response May Suppress Innate Immunity Through the Activation of a Noncanonical Glucocorticoid Signaling Pathway

In this study, David van Westerloo and colleagues from the University of Amsterdam report that bungee jumping resulted in a time-dependent increase in the plasma concentrations of epinephrine, norepinephrine and cortisol; decreased whole blood production of TNF-alpha and IL-8, and a substantial reduction of bacterial phagocytosis by granulocytes and monocytes. Bungee jumping may represent an […]

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