stress and disease

The Burden of Stress in America 2014 Survey

The Burden of Stress in America 2014 Survey

The survey was conducted from March 5 to April 8, 2014 with a sample of 2,505 respondents. The poll was developed by researchers at the Harvard Opinion Research Program (HORP) at the Harvard School of Public Health in partnership with the Robert Wood Johnson Foundation and NPR. Some highlights and results from the survey: — […]

Large Population Study Links Stress in Middle Age Women to Dementia and Alzheimer’s Risk Decades Later

Large Population Study Links Stress in Middle Age Women to Dementia and Alzheimer’s Risk Decades Later

A Swedish study, published in the August 2013 online issue of BMJ Open indicates that a higher number of psychosocial stressors in middle-aged women were associated with increased risk of dementia and Alzheimer’s disease (AD) decades later in life. This is perhaps the first population study on the relationship between midlife stressors and increased risk […]

Stress and Worrying Affect Short-Term Fluctuations in Rheumatoid Arthritis Symptoms

Stress and Worrying Affect Short-Term Fluctuations in Rheumatoid Arthritis Symptoms

In the July 2013 issue of Annals of Rheumatic Diseases, Evers et al. report that stress and worrying predict indicators of rheumatoid arthritis disease activity such as fatigue and pain. Psychological stress has been linked to the onset and course of rheumatoid arthritis (RA). While for the juvenile chronic arthritis (JCA), chronic stress appear to […]

‘Toxic’ News Overload versus Creativity and Deep Thinking

‘Toxic’ News Overload versus Creativity and Deep Thinking

Information overload is not a newly discovered phenomenon, but recently Rolf Dobelli provided some interesting thoughts and discussions about the detrimental influence on individuals and societies by the “toxic form of knowledge” called “news.” Moreover, in an essay entitled: “Avoid News: Towards a Healthy News Diet” he offers some ideas “how to get out of […]

Corticotropin-Releasing Hormone’s Inhibition of NLRP6 Inflammasome May Trigger Stress-Induced Enteritis in Mice

Corticotropin-Releasing Hormone’s Inhibition of NLRP6 Inflammasome May Trigger Stress-Induced Enteritis in Mice

In the June 2013 issue of Gastroenterology, Sun et al. demonstrate that in mice stress is able to inhibit NLRP6, through a corticotropin-releasing hormone (CRH)-dependent mechanism and to modify the composition of the gut microbiota, leading to intestinal inflammation. It is well known that psychological stress exacerbates the symptoms of irritable bowel syndrome (IBS). Also, […]

Chronic Variable Stress May Promote Autoimmunity through Induction of Glucocorticoid Resistance

Chronic Variable Stress May Promote Autoimmunity through Induction of Glucocorticoid Resistance

A new European Journal of Immunology study links chronic stress and autoimmunity through a mechanism referred to as glucocorticoid resistance. The effect of psychological stress on autoimmunity is extremely complex, at multiple levels, and can be in either direction. Often, stress is related to both induction/exacerbation and amelioration of disease activity. Stress hormones selectively suppress […]

Combat-training stress and high pro-inflammatory markers in soldiers linked to increased intestinal permeability and gastrointestinal symptoms

Combat-training stress and high pro-inflammatory markers in soldiers linked to increased intestinal permeability and gastrointestinal symptoms

A study published in the February 2013 issue of Alimentary Pharmacology and Therapeutics reports that soldiers participating in as little as 6 weeks of combat training had high stress; anxiety and depression levels combined with gastrointestinal (GI) symptoms, pro-inflammatory immune activation and increased intestinal permeability. Gastrointestinal symptoms in soldiers are among the most common causes […]

Prenatal Immune Challenge – ‘Disease Primer’ Increasing the Offspring’s Vulnerability to Stress

Prenatal Immune Challenge – ‘Disease Primer’ Increasing the Offspring’s Vulnerability to Stress

A recent study published in Science is probably the first to provide evidence suggesting that prenatal immune challenge can function as a “disease primer” that amplifies the offspring’s susceptibility to stress and its detrimental neuro-pathological effects in peri-pubertal life. Epidemiologic studies indicate that prenatal infection may play an important role in the etiopathogenesis of schizophrenia, […]

Stress promotes tumor growth by amplifying the cancer cells’ ability to evade apoptosis

Stress promotes tumor growth by amplifying the cancer cells’ ability to evade apoptosis

A study published in the Journal of Clinical Investigation indicates that stress or the stress hormone adrenaline, through stimulation of beta-adrenoreceptors (ADRs), activate signaling pathways that lead to the inhibition of apoptosis. This enables prostate cancer cells to evade apoptosis, which is an important feature of tumor growth and metastasis. An increasing body of evidence […]

Neurotensin, CRH and Mast Cell Activation: Implications for Stress-Induced Exacerbations of Allergic Diseases

Neurotensin, CRH and Mast Cell Activation: Implications for Stress-Induced Exacerbations of Allergic Diseases

A study published in PLoS One indicates the presence of distinctive interactions between neurotensin (NT), corticotropin-releasing hormone (CRH) and mast cells that may be involved in inflammatory- and/or stress-related diseases. Psychological stress is known to aggravate asthma, migraines and certain autoimmune/inflammatory diseases. Although the mechanisms of stress-induced exacerbations of these conditions are not fully understood, […]

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