sensory nerve

Neural Meshwork Resembling Glass Fishing Float Envelops Antigen Presenting Cells in Lymphoid Organs

Neural Meshwork Resembling Glass Fishing Float Envelops Antigen Presenting Cells in Lymphoid Organs

Commentary on the study by Clemens Wülfing & Hauke S. Günther, Sci Rep, 2015, 5:16866 ‘Dendritic cells and macrophages neurally hard-wired in the lymph node’ The sympathetic neuronal control of immunity in primary and secondary lymphoid organs is exerted through “hard-wired” noradrenergic nerve terminals through the release of norepinephrine that interacts with the immune cells. […]

Vitamin D Deficiency May Contribute to the Reduction of Sympathetic and Sensory Innervation in Arthritis

Vitamin D Deficiency May Contribute to the Reduction of Sympathetic and Sensory Innervation in Arthritis

A new study published in Neuroscience demonstrates that vitamin D deficiency in experimental animals is related to sensory and sympathetic denervation and reduced neurotrophin levels in the synovium. Several studies have associated vitamin D levels with rheumatoid arthritis (RA) development in humans. Thus, low vitamin D levels are documented in patients with active RA. Also […]

Therapeutic Potential of α7 Nicotinic Acetylcholine Receptor Agonists in a Murine Model of Rheumatoid Arthritis

Therapeutic Potential of α7 Nicotinic Acetylcholine Receptor Agonists in a Murine Model of Rheumatoid Arthritis

According to van Maanen et al., and their recent publication in PLoS One, two new experimental compounds affecting the acetylcholine-receptor system are able to delay collagen-induced arthritis (CIA) in mice, showing the therapeutic potential of chemicals targeting the α7 subunit of nicotinic acetylcholine receptors (α7nAChR). Previous research revealed that the efferent vagus nerve may decrease […]

TRPV1 Sensory Nerves May Be Key to the Genesis of Airway Hyperreactivity in Experimental Asthma

TRPV1 Sensory Nerves May Be Key to the Genesis of Airway Hyperreactivity in Experimental Asthma

A new study in the Proceedings of the National Academy of Sciences (PNAS) of the USA implicates the transient receptor potential vanilloid 1 (TRPV1)-expressing sensory nerves in the pathogenesis of asthma and/or asthma attacks. The TRPV1 receptor, initially identified as the receptor for capsaicin, the hot component of chilli peppers, is typically expressed in sensory […]

Vagus Nerve Stimulation Ameliorates Disease Activity in a Rodent Model of Rheumatoid Arthritis

Vagus Nerve Stimulation Ameliorates Disease Activity in a Rodent Model of Rheumatoid Arthritis

A study published in PLoS ONE is perhaps the first to demonstrate that electrical neurostimulation of the vagus nerve reduces signs of inflammation and disease severity in the collagen-induced arthritis (CIA), a disease model of rheumatoid arthritis in rodents. Previous research indicates that cholinergic signaling along the vagus nerve is able to affect the production […]

Acid Sensing By Sensory Neurons in Inflammation

Acid Sensing By Sensory Neurons in Inflammation

Overview article Chronic inflammatory conditions, such as rheumatoid arthritis (RA), are characterized by continuous pain and RA is the most frequent form of inflammatory joint disease in the United Kingdom [1] with an estimated economic cost of ~£8bn/year [2]. Inflammation has several notable symptoms including the four cardinal ones described by Aulus Cornelius Celsus in […]

Neuroendocrine-Immune Interactions in Lung Inflammatory Diseases

Neuroendocrine-Immune Interactions in Lung Inflammatory Diseases

Overview article Inflammation is the body’s response to insults. During inflammation, various inflammatory cells are activated to release cytokines and mediators and orchestrate progressing inflammation. Clinically, pneumonia and acute respiratory distress syndrome involve acute inflammation, whereas asthma and chronic obstructive pulmonary diseases represent chronic inflammation. Inflammation is regulated by both the immune and neuroendocrine systems. […]

Role of the Vagus Nerve at the Neural-Immune Interface

Role of the Vagus Nerve at the Neural-Immune Interface

Overview article Evidence shows that the central nervous system monitors and modulates the activity of both circulating and tissue immune cells via the neuroendocrine system and autonomic nerves. Furthermore, findings over the last decade have demonstrated that the vagus nerve represents an important bi-directional link between the brain and immune system. Afferent vagal pathways transmit […]