psychological stress

Cytokines: Stress and Immunity, 2nd Edition

Homeostasis within the immune system is largely dependent on cytokines, the chemical messengers between immune cells. These diverse groups of proteins may be regarded as hormones of the immune system that play crucial roles in regulating immune and inflammatory responses. Pro-inflammatory cytokines, released during an immune response and inflammation activate the central components of the […]

Stress and Catecholamines Up-Regulate Proinflammatory Cytokine Production and Neutrophil Infiltration in Experimental Colitis

Stress and Catecholamines Up-Regulate Proinflammatory Cytokine Production and Neutrophil Infiltration in Experimental Colitis

A recent Brain, Behavior and Immunity study indicates that psychological stress contributes to the exacerbation of the murine model of colitis by promoting the mobilization and entry of neutrophils in the colon. This appears to be achieved by the up-regulation of pro-inflammatory cytokine and chemokine production and STAT3 signaling, and involves β1/β2-adrenergic receptors activation. Inflammatory […]

Hans Selye and the 80th Birthday of Stress Research

Hans Selye and the 80th Birthday of Stress Research

Stress research has been around for 80 years but has perhaps never been more actual and trendy as in recent years. The term ‘stress’ (psychological) is extremely popular and the general public, as well as celebrities, frequently use and occasionally abuse this term to describe situations causing agitation or alteration of their wellbeing. In PubMed, […]

The Stress of Life

The Stress of Life, a classic book written by the man who introduced the term (psychological) “stress” and “dedicated his entire scientific career to furnish more and more proof for the importance of neuroendocrine mechanisms in the development of disease. János Hugo Bruno “Hans” Selye (January 26, 1907 – October 16, 1982) was a pioneering […]

New Evidence That Psychological Stress Contributes To Peptic Ulcers Development

New Evidence That Psychological Stress Contributes To Peptic Ulcers Development

A new study published in the journal Clinical Gastroenterology and Hepatology provides new evidence that stress is related to an increased risk of peptic ulcers. Since the pioneering work of Hans Selye in the 1930s, psychological stress was often linked to the induction and progression of peptic ulcers. In the 1950s-60s, Selye began to promote […]

The Association of Body Composition and Novel Bioimpedance Measurements with Chronic Stress and Inflammation Biomarkers

The Association of Body Composition and Novel Bioimpedance Measurements with Chronic Stress and Inflammation Biomarkers

A recent study by Constantine Tsigos et al., published in the European Journal of Clinical Investigation (EJCI) indicates that the presence of ‘medically unexplainable symptoms’ (MUS) is an index of chronic stress and inflammation, and that advanced bioimpedance analysis may provide a useful, bloodless and rapid tool in the clinical setting. Chronic stress plays two […]

The Power of Positive Stress and a Research Roadmap

The Power of Positive Stress and a Research Roadmap

Evolving Concepts Stress is everywhere. In evolutionary terms, given the range of stressful environmental challenges faced, the human race could not have evolved without developing successful physiological strategies to cope with and overcome potentially life-threatening challenges on a daily basis. The need for a robust response to an acute stress is well-established. Not only do […]

Anxiety, Depression and Obesity May Jointly Contribute To Asthma Development

Anxiety, Depression and Obesity May Jointly Contribute To Asthma Development

A recent study by M. Brumpton et al., published in the International Journal of Epidemiology has shed light on the complex interactions and joint effects of anxiety, depression and obesity on the onset and development of asthma. Approximately 300 million people suffer from asthma, amounting to nearly 1% of the total global disease burden, worldwide. […]

Evidence that Napping May Correct Interleukin-6 Changes and the Stress Induction Caused By Sleep Deprivation

Evidence that Napping May Correct Interleukin-6 Changes and the Stress Induction Caused By Sleep Deprivation

A study published in the March issue of The Journal of Clinical Endocrinology & Metabolism (JCEM) indicates that short-term napping is able to restore, to a great extent, the neurohormonal and immune changes induced by sleep deprivation. Insufficient sleep is well-known to be associated with poor attention and performance deficits. However, an increasing body of […]

Childhood Adversities and the Development of Asthma in Adulthood

Childhood Adversities and the Development of Asthma in Adulthood

Recently the BMJ Open online journal published the first large-scale prospective, population-based study, involving 24 057 participants, followed for a 7-year period, documenting an association between childhood adversities and register-verified asthma diagnosis in adulthood. Previous research has shown that anxiety disorders and major depression are linked to asthma development, and two previous longitudinal studies reported […]

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