psychological stress and autoimmune disease

Chronic Variable Stress May Promote Autoimmunity through Induction of Glucocorticoid Resistance

Chronic Variable Stress May Promote Autoimmunity through Induction of Glucocorticoid Resistance

A new European Journal of Immunology study links chronic stress and autoimmunity through a mechanism referred to as glucocorticoid resistance. The effect of psychological stress on autoimmunity is extremely complex, at multiple levels, and can be in either direction. Often, stress is related to both induction/exacerbation and amelioration of disease activity. Stress hormones selectively suppress […]

Stress & Organ Specific Autoimmunity: A Complex Interrelationship

Stress & Organ Specific Autoimmunity: A Complex Interrelationship

OVERVIEW ARTICLE The evidence for stress contributing to the onset and course of autoimmune disease is circumstantial and the mechanisms by which stress affects autoimmune disease remain poorly understood. The best evidence for an effect of stress on the development of an autoimmune disorder is the well-known relationship between the clinical onset of Graves’ hyperthyroidism, […]