proinflammatory cytokines

Experimental Study Shows Link between Cerebrospinal Fluid IL-6 and Depressive Symptoms in Humans

Experimental Study Shows Link between Cerebrospinal Fluid IL-6 and Depressive Symptoms in Humans

A recent study published in Molecular Psychiatry suggests that the appearance of depressive symptoms in inflammatory conditions might be primarily linked to an increase in central IL-6 concentration. Inflammation is a physiological response to infection and tissue injury that involves the release of pro-inflammatory (e.g., TNF-α, IL-6) and anti-inflammatory (e.g., IL-10) cytokines from activated immune […]

High Levels of the Pro-Inflammatory Cytokines IL-1β and IL-6 Found in Patients with Suicidality

High Levels of the Pro-Inflammatory Cytokines IL-1β and IL-6 Found in Patients with Suicidality

A recent  study published in the journal Biological Psychiatry indicates the presence of aberrant cytokine levels in patients with suicidality, and identifies a link between pro-inflammatory cytokines, and specifically, interleukin (IL)-1β and IL-6 with suicidal behavior. Previous research has shown that major depression is associated with an immune response with an increased production of pro-inflammatory […]

Tumor Necrosis Factor Modulates Bitter Taste Responses

Tumor Necrosis Factor Modulates Bitter Taste Responses

A new study by Pu Feng and colleagues from the Monell Chemical Senses Center, Philadelphia, USA, published in Brain, Behavior, and Immunity indicates that tumor necrosis factor (TNF)-α, a major pro-inflammatory cytokine is involved in the regulation of bitter taste reception. Whether inflammatory cytokines contribute to taste reception or regulation is poorly understood. TNF is […]

Magnified Peripheral IL-6 Response Linked To Stress Susceptibility and Higher Risk of Depression

Magnified Peripheral IL-6 Response Linked To Stress Susceptibility and Higher Risk of Depression

A new study published in the Proceedings of the National Academy of Sciences of the USA is perhaps the first to demonstrate that the magnitude of peripheral interleukin (IL)-6 responses preceding stress challenge may confer inter-individual differences in susceptibility or resilience to a subsequent social stressor. Previous research indicates that in humans both major depression […]

IL-17: A Promising Therapeutic Target in Several Chronic Inflammatory Diseases

IL-17: A Promising Therapeutic Target in Several Chronic Inflammatory Diseases

Commentary on the study by Dominique L. P. Baete and Vijay K. Kuchroo Nat Med. 2013 Jul;19(7):824-5 How Cytokine networks fuel inflammation: Interleukin-17 and a tale of two autoimmune diseases Since the discovery of T helper 17 (Th17) cells, an increasing body of evidence indicates that these cells play a major role in the development […]

A Hierarchical Cytokines Framework Defining Groups of Chronic Inflammatory Diseases: Learning From Cytokine-Targeted Therapies

A Hierarchical Cytokines Framework Defining Groups of Chronic Inflammatory Diseases: Learning From Cytokine-Targeted Therapies

Commentary on the study by George Schett et al, Nat Med, 2013 Jul;19(7):822-4 How cytokine networks fuel inflammation: Toward a cytokine-based disease taxonomy Extensive genome-wide association and epidemiological studies have shed light on the causes of chronic inflammatory diseases and have confirmed a central role of the immune system and particularly of cytokines [1]. Secreted […]

Interferon and the Central Nervous System

Interferon and the Central Nervous System

Overview article Interferons (IFNs) are glycoproteins known as cytokines. These cytokines got their name by Isaacs and Lindenmann [1] after their ability to interfere with viral growth and production. Isaacs and Lindenmann worked at the Medical Research Council Laboratory in Mill Hill, outside London and were the first to publish a paper on these proteins. […]

Gerald Weissmann, Meryl Streep, Mechnikov and Inflammation: It’s Complicated

Gerald Weissmann, Meryl Streep, Mechnikov and Inflammation: It’s Complicated

SHORT FEATURES and FACES ARTICLE In a recent Editorial, Gerald Weissmann, in his typical elegant and provocative style, mingles Hollywood stars and movie characters with some major pathology phenomena. The recent movie ‘It’s Complicated’ inspired the Editor-in-Chief of the FASEB journal to find some striking similarities between some of the movie’s features and the cardinal […]

Nerve Growth Factor and Inflammation: A Complex Bidirectional Interaction

Nerve Growth Factor and Inflammation: A Complex Bidirectional Interaction

Overview article The nervous and immune systems share common functions: both are involved in adapting the body to the environment and in maintaining homeostasis. Because they are the two major adaptive systems of the body it is not surprising that they have developed common strategies: both are able to sense external and internal variations, which […]