norepinephrine and pain

Disruption of Brain TNF Homeostasis Elicits Maladaptive Alterations Producing Chronic Pain

Disruption of Brain TNF Homeostasis Elicits Maladaptive Alterations Producing Chronic Pain

OVERVIEW ARTICLE We have determined that enhanced expression of the pro-inflammatory cytokine Tumor Necrosis Factor-α (TNF) by both neurons and glial cells of the brain direct the process involved with the development and also the maintenance of neuropathic pain. However, TNF is not only a pro-inflammatory cytokine but is also a potent neuromodulator. TNF specially […]