neuroscience and immunology

Psychoneuroimmunology, Two-Volume Set, Volume 1-2, Fourth Edition

Psychoneuroimmunology provides comprehensive and up-to-date information on the vast interdisciplinary research area that covers the interactions between the brain and the immune system. The revised and updated fourth edition offers experts opinions and overviews of the behavioral and neuroendocrine effects on the immune system, and vice versa, effects of immune system activity on brain functions. […]

Acid Sensing By Sensory Neurons in Inflammation

Acid Sensing By Sensory Neurons in Inflammation

OVERVIEW ARTICLE Chronic inflammatory conditions, such as rheumatoid arthritis (RA), are characterized by continuous pain and RA is the most frequent form of inflammatory joint disease in the United Kingdom [1] with an estimated economic cost of ~£8bn/year [2]. Inflammation has several notable symptoms including the four cardinal ones described by Aulus Cornelius Celsus in […]

Hyperactive Type I Interferon System in the Choroid Plexus Linked To Aging and Cognitive Dysfunction

Hyperactive Type I Interferon System in the Choroid Plexus Linked To Aging and Cognitive Dysfunction

A study published in the August 21, 2014 issue of Science magazine demonstrates that aging is associated with an overactive IFN-I system at a specific brain structure, the choroid plexus. This vascular tissue, found in all cerebral ventricles, is an epithelial monolayer that forms the blood-cerebrospinal fluid barrier, and, in fact, represents the ‘interface’ between […]

Endogenous Catecholamines in Immune Cells: Discovery, Functions And Clinical Potential as Therapeutic Targets

Endogenous Catecholamines in Immune Cells: Discovery, Functions And Clinical Potential as Therapeutic Targets

OVERVIEW ARTICLE The catecholamines dopamine, noradrenaline and adrenaline are well established neurotransmitters and neurohormones. Sympathoadrenergic pathways are pivotal to the communication between the nervous system and the immune system, and the role of dopaminergic pathways in the modulation of immune response is being increasingly unveiled. However, over the last two decades, evidence has accumulated regarding […]

Interferon and the Central Nervous System

Interferon and the Central Nervous System

OVERVIEW ARTICLE Interferons (IFNs) are glycoproteins known as cytokines. These cytokines got their name by Isaacs and Lindenmann [1] after their ability to interfere with viral growth and production. Isaacs and Lindenmann worked at the Medical Research Council Laboratory in Mill Hill, outside London and were the first to publish a paper on these proteins. […]