neuroimmunology

Disruption of Brain TNF Homeostasis Elicits Maladaptive Alterations Producing Chronic Pain

Disruption of Brain TNF Homeostasis Elicits Maladaptive Alterations Producing Chronic Pain

OVERVIEW ARTICLE We have determined that enhanced expression of the pro-inflammatory cytokine Tumor Necrosis Factor-α (TNF) by both neurons and glial cells of the brain direct the process involved with the development and also the maintenance of neuropathic pain. However, TNF is not only a pro-inflammatory cytokine but is also a potent neuromodulator. TNF specially […]

Th17 and Th22 Cells May Contribute To the Pathogenesis of Guillain-Barré Syndrome

Th17 and Th22 Cells May Contribute To the Pathogenesis of Guillain-Barré Syndrome

A study by Shujuan Li and colleagues from the Jilin University, Changchun, China, suggests that Th17 and Th22 cells might be involved in the onset and development of Guillain-Barré Syndrome. T helper (Th)17 cells and the interleukin (IL)-23→IL-17 axis drive chronic inflammation in many autoimmune diseases. The report by Li et al, published in the […]