neurohormonal-immune interactions

Immunoendocrinology in Health and Disease

The first part of this book (pp. 1-415) is devoted to the fundamental aspects of the interactions between the adaptive immune system and the endocrine system. After a global view of immunological development and biology, 19 chapters extensively present the state of knowledge about the influence upon the immune response exerted by peptide hormones (growth […]

Neuroendocrine Immunology of Rheumatic Diseases: A 10-Year Update

Neuroendocrine Immunology of Rheumatic Diseases: A 10-Year Update

In 2001, Drs. Rainer Straub and Maurizio Cutolo, established experts in the field of neuroendocrine immunology of autoimmune and rheumatic diseases, published a large overview on the role of diverse neural and hormonal factors in rheumatoid arthritis. In the last decade, Maurizio Cutolo, president of the European League against Rheumatism (EULAR) has also organized the […]

ATP as a Neuromediator at the Brain-Immune Interface

ATP as a Neuromediator at the Brain-Immune Interface

OVERVIEW ARTICLE The purinergic signaling system, also known as a ‘purinome’, represents extracellular signaling cascades, which are mediated by Adenosine Triphosphate (ATP) and its extracellular breakdown product, adenosine. This system consists of receptors, enzymes and transporters responsible for their release, actions and extracellular inactivation (Figure 1). ATP is well-known as the universal ‘energy currency’ of […]

The Neuroimmune Biology of Vasopressin

The Neuroimmune Biology of Vasopressin

OVERVIEW ARTICLE Vasopressin (VP) has emerged in recent years as a very important immunoregulatory peptide of the hypothalamus. VP is capable of maintaining immune function, both innate and adaptive immunity. This is due to the ability of VP to stimulate both the hypothalamic-pituitary-adrenal (HPA) axis and prolactin (PRL) secretion. The HPA axis is important for […]