neural immune interactions pathways connections

The Psychoneuroimmunology of Chronic Disease: Exploring the Links between Inflammation, Stress, and Illness

The Psychoneuroimmunology of Chronic Disease delves into the complex interactions between the brain and immune system, and between inflammation, stress and human diseases. Importantly, it also offers both fundamental and clinical perspectives on how these interactions may influence common complex inflammatory maladies such as heart disease, diabetes, multiple sclerosis, Alzheimer s, and autoimmune disorders. The […]

Brain-Immune Signaling: Focus on Pathogen Recognition and PGE2 Synthesis

Brain-Immune Signaling: Focus on Pathogen Recognition and PGE2 Synthesis

Overview article The body’s reaction to infections involves the orchestration of multiple systems to effectively initiate, execute and resolve the immune response. At the core of these adaptive processes are the cellular and molecular neural, immune and endocrine interactions that begin with the central nervous system recognizing the presence of an infection. The mediator prostaglandin […]

Innervation of the Human Thymus and Spleen – an Overview

Innervation of the Human Thymus and Spleen – an Overview

Overview article The immune and nervous systems are anatomically and functionally interconnected, this cross-talk is evidenced by the dense innervation – mainly sympathetic – of the primary (bone marrow and thymus) and secondary (spleen and lymph nodes) lymphoid organs [1, 2]. Primary and secondary lymphoid organs are innervated by the autonomic nervous system resulting in […]

Role of the Vagus Nerve at the Neural-Immune Interface

Role of the Vagus Nerve at the Neural-Immune Interface

Overview article Evidence shows that the central nervous system monitors and modulates the activity of both circulating and tissue immune cells via the neuroendocrine system and autonomic nerves. Furthermore, findings over the last decade have demonstrated that the vagus nerve represents an important bi-directional link between the brain and immune system. Afferent vagal pathways transmit […]