lung disease

TRPV1 Sensory Nerves May Be Key to the Genesis of Airway Hyperreactivity in Experimental Asthma

TRPV1 Sensory Nerves May Be Key to the Genesis of Airway Hyperreactivity in Experimental Asthma

A new study in the Proceedings of the National Academy of Sciences (PNAS) of the USA implicates the transient receptor potential vanilloid 1 (TRPV1)-expressing sensory nerves in the pathogenesis of asthma and/or asthma attacks. The TRPV1 receptor, initially identified as the receptor for capsaicin, the hot component of chilli peppers, is typically expressed in sensory […]

Neuroendocrine-Immune Interactions in Lung Inflammatory Diseases

Neuroendocrine-Immune Interactions in Lung Inflammatory Diseases

OVERVIEW ARTICLE Inflammation is the body’s response to insults. During inflammation, various inflammatory cells are activated to release cytokines and mediators and orchestrate progressing inflammation. Clinically, pneumonia and acute respiratory distress syndrome involve acute inflammation, whereas asthma and chronic obstructive pulmonary diseases represent chronic inflammation. Inflammation is regulated by both the immune and neuroendocrine systems. […]