inflammatory bowel disease

Stress and Catecholamines Up-Regulate Proinflammatory Cytokine Production and Neutrophil Infiltration in Experimental Colitis

Stress and Catecholamines Up-Regulate Proinflammatory Cytokine Production and Neutrophil Infiltration in Experimental Colitis

A recent Brain, Behavior and Immunity study indicates that psychological stress contributes to the exacerbation of the murine model of colitis by promoting the mobilization and entry of neutrophils in the colon. This appears to be achieved by the up-regulation of pro-inflammatory cytokine and chemokine production and STAT3 signaling, and involves β1/β2-adrenergic receptors activation. Inflammatory […]

Dysfunctional Sympathetic-Immune Interface in Disease States of the Gastrointestinal Tract

Dysfunctional Sympathetic-Immune Interface in Disease States of the Gastrointestinal Tract

OVERVIEW ARTICLE The sympathetic nervous system (SNS) is an integrative interface between the central nervous system and viscera that contributes to the maintenance of homeostasis. It is comprised of cholinergic preganglionic sympathetic neurons which innervate postganglionic sympathetic neurons (PGSNs) and adrenal chromaffin cells (ACCs). Catecholamines and sympathetic co-transmitters, including adenosine triphosphate (ATP), or a related […]

Pro- and Anti-Inflammatory Effects of Stress in the Brain: Mechanisms and Implications

Pro- and Anti-Inflammatory Effects of Stress in the Brain: Mechanisms and Implications

OVERVIEW ARTICLE Some stress protocols show a pro-inflammatory response in the brain and other systems characterized by a complex release of several inflammatory mediators such as cytokines, transcription factors, prostanoids and free radicals. Such response might contribute to cell damage during several neuropsychiatric diseases related with stress (post-traumatic stress disorder, major depressive disorder, anxiety disorders, […]