immunosenescence

Aging Alters Sympathetic Noradrenergic Innervation and Immune Reactivity in the Lymphoid Organs: Strategies to Reverse Neuro-Immune Senescence

Aging Alters Sympathetic Noradrenergic Innervation and Immune Reactivity in the Lymphoid Organs: Strategies to Reverse Neuro-Immune Senescence

Overview article Current therapeutic strategies in medicine emphasize the influence of “mind” over “body” in the maintenance of health and development, progression, and recovery from diseases. This is achieved by interactions between the nervous system, endocrine system, and immune system in controlling health and disease mediated through various psychological, emotional, and spiritual factors. Several studies […]

Developmental Changes in the Neuroendocrine/Stress-Immune Interactions: Immunosenescence and Infectious/Inflammatory Disease Risk in the Elderly

Developmental Changes in the Neuroendocrine/Stress-Immune Interactions: Immunosenescence and Infectious/Inflammatory Disease Risk in the Elderly

In a recent review, Kathi Heffner from the Department of Psychiatry, University of Rochester Medical Center, Rochester, New York outlines recent data suggesting that immunosenescence, endocrinosenescence and age-related dysregulation of stress response systems are closely intertwined. Immunosenescence refers to the dysfunction and gradual deterioration of the immune system associated with aging. This overall change in […]

Tumor Necrosis Factor – a Possible Link Between Age-Related Endocrine Dyscrasia and Alzheimer’s Disease

Tumor Necrosis Factor – a Possible Link Between Age-Related Endocrine Dyscrasia and Alzheimer’s Disease

In a commentary recently published in the Journal of Alzheimer’s Disease, Ian Clark and Craig Atwood discussed some novel mechanisms and viewpoints related to the “cross-talk” between tumor necrosis factor (TNF) and endocrine dyscrasia, and how this might affect the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD), stroke and traumatic brain disease. Endocrine dyscrasia […]