IL-6

Experimental Study Shows Link between Cerebrospinal Fluid IL-6 and Depressive Symptoms in Humans

Experimental Study Shows Link between Cerebrospinal Fluid IL-6 and Depressive Symptoms in Humans

A recent study published in Molecular Psychiatry suggests that the appearance of depressive symptoms in inflammatory conditions might be primarily linked to an increase in central IL-6 concentration. Inflammation is a physiological response to infection and tissue injury that involves the release of pro-inflammatory (e.g., TNF-α, IL-6) and anti-inflammatory (e.g., IL-10) cytokines from activated immune […]

Personality Traits like Extraversion and Conscientiousness Linked to Pro-Inflammatory Genes Expression

Personality Traits like Extraversion and Conscientiousness Linked to Pro-Inflammatory Genes Expression

A study published in the journal Psychoneuroendocrinology demonstrates that leukocyte gene expression correlates with two major dimensions of human personality, extraversion and conscientiousness. A recent study in nonhuman primates provides new insights into the neuroanatomical basis of personality, showing that personality traits are linked to the anatomy of specific brain structures such as the anterior […]

High Levels of the Pro-Inflammatory Cytokines IL-1β and IL-6 Found in Patients with Suicidality

High Levels of the Pro-Inflammatory Cytokines IL-1β and IL-6 Found in Patients with Suicidality

A recent  study published in the journal Biological Psychiatry indicates the presence of aberrant cytokine levels in patients with suicidality, and identifies a link between pro-inflammatory cytokines, and specifically, interleukin (IL)-1β and IL-6 with suicidal behavior. Previous research has shown that major depression is associated with an immune response with an increased production of pro-inflammatory […]

Evidence that Napping May Correct Interleukin-6 Changes and the Stress Induction Caused By Sleep Deprivation

Evidence that Napping May Correct Interleukin-6 Changes and the Stress Induction Caused By Sleep Deprivation

A study published in the March issue of The Journal of Clinical Endocrinology & Metabolism (JCEM) indicates that short-term napping is able to restore, to a great extent, the neurohormonal and immune changes induced by sleep deprivation. Insufficient sleep is well-known to be associated with poor attention and performance deficits. However, an increasing body of […]

The Combination of Cortisol Diurnal Variation, IL-6 and TNF-α as Potential Diagnostic Marker in Autism

The Combination of Cortisol Diurnal Variation, IL-6 and TNF-α as Potential Diagnostic Marker in Autism

A study published in the Research in Autism Spectrum Disorders Journal indicates that cortisol, IL-6 and TNF-α may become useful markers for autism spectrum disorder (ASD). At present, 1 in 68 children in the US, and 1 in 100, in the UK, develop ASD. This is approximately a 30% increase versus the previous estimates reported […]

Magnified Peripheral IL-6 Response Linked To Stress Susceptibility and Higher Risk of Depression

Magnified Peripheral IL-6 Response Linked To Stress Susceptibility and Higher Risk of Depression

A new study published in the Proceedings of the National Academy of Sciences of the USA is perhaps the first to demonstrate that the magnitude of peripheral interleukin (IL)-6 responses preceding stress challenge may confer inter-individual differences in susceptibility or resilience to a subsequent social stressor. Previous research indicates that in humans both major depression […]

Sarcopenia, the Skeletal Muscle as an Endocrine Organ and Aging

Sarcopenia, the Skeletal Muscle as an Endocrine Organ and Aging

In a recent review, Drs. A. Pratesi, F. Tarantini and M. Di Bari discuss major hormonal and immune mechanisms that drive the age-related decline in muscle quantity and quality. Besides the hormonal factors, the authors outline the role of some skeletal muscles mediators, termed ‘myokines’ that act in an autocrine, paracrine, or ‘hormone-like’ fashion. This […]

Immune & Cytokine Dysregulation Associated With Behavioral Deficits In A Mouse Model Of Autism

Immune & Cytokine Dysregulation Associated With Behavioral Deficits In A Mouse Model Of Autism

A new report in the Proceedings of the National Academy of Sciences of the USA (PNAS) indicates that cellular and cytokine immune dysregulation may contribute to the autism spectrum disorder (ASD)-related behavioral deficits in a mouse model of an autism. Recent evidence indicates the involvement of an abnormal immune system activity in the pathogenesis of […]

Interleukin-6 – a Better Predictor of Future Cardiovascular Events Than C-Reactive Protein?

Interleukin-6 – a Better Predictor of Future Cardiovascular Events Than C-Reactive Protein?

In a study published in the journal Cytokine, Hidenori Nishida and colleagues from the National Cerebral and Cardiovascular Center, Suita, Japan, demonstrate that an increased level of serum IL-6 is a significant predictor of future cardiovascular (CV) events in high-risk Japanese patients, independently of a variety of influencing factors. One of the paradigm shifts in […]

Negative and Competitive Interpersonal Stressors Linked to High Proinflammatory Cytokine Responses

Negative and Competitive Interpersonal Stressors Linked to High Proinflammatory Cytokine Responses

In a recent PNAS study, Jessica Chiang and colleagues from the Department of Psychology, David Geffen School of Medicine, University of California, Los Angeles, investigated the potential importance of negative, competitive and positive daily interactions on inflammatory activity. The authors of this study demonstrate that negative social interactions significantly predicted higher baseline levels of sTNFaRII […]

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