IL-33

Rhinovirus Infections via ATP Release May Trigger IL-33 Production by Bronchial Smooth Muscle Cells: Implications for Asthma

Rhinovirus Infections via ATP Release May Trigger IL-33 Production by Bronchial Smooth Muscle Cells: Implications for Asthma

A recent Journal of Translational Medicine study indicates that interleukin (IL)-33 is produced by bronchial smooth muscle cells (BSMCs) upon rhinovirus (RV) infection and activation of TLR3, and that this response is associated and/or mediated by ATP released by viral-stimulated BSMCs. IL-33 is a cytokine constitutively expressed in epithelial barrier tissues, and was originally described […]

Interactions Among IL-33, Substance P and Mast Cells May Contribute to the Pathogenesis of Psoriasis

Interactions Among IL-33, Substance P and Mast Cells May Contribute to the Pathogenesis of Psoriasis

A new study published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) indicates that substance P (SP) stimulates human mast cells to secrete vascular endothelial growth factor (VEGF) and that this action is augmented by interleukin (IL)-33. Substance P-positive nerve fibers are denser in psoriatic lesions and […]

Overview of the ”New Generation” Cytokines

Overview of the ”New Generation” Cytokines

In this review, Cem Gabay and Iain McInnes present the biology and relevant pathophysiology of several novel cytokines, with focus on their involvement in rheumatic diseases. This list includes the IL-1 superfamily (IL-18 and IL-33), the IL-12 superfamily (IL-27 and IL-35), the IL-2 superfamily (IL-15 and IL-21), and IL-17. The authors conclude that in the […]