IL-17

Glucocorticoid Resistance of Th17 Cells in Takayasu Arteritis

Glucocorticoid Resistance of Th17 Cells in Takayasu Arteritis

A study published in the Arthritis & Rheumatology journal is perhaps the first to demonstrate that T helper (Th)1 and Th17 cells and cytokine pathways may play central role in driving systemic inflammation in Takayasu arteritis. Takayasu arteritis (TA) is a rare type of vasculitis that affects mostly middle-aged women, with greater frequency in Asia, […]

Blood Levels of the New Anti-Inflammatory Cytokine IL-37 Are Increased In Rheumatoid Arthritis Patients

Blood Levels of the New Anti-Inflammatory Cytokine IL-37 Are Increased In Rheumatoid Arthritis Patients

A recent study published in PLoS One suggests that interleukin (IL)-17 is involved in a control circuit that tries to regulate inflammation in rheumatoid arthritis. Rheumatoid arthritis (RA) is associated with increased levels of pro-inflammatory cytokines such as IL-6, IL-17A and tumor necrosis factor (TNF)-α. Early intervention and treatment of RA is based on disease-modifying […]

New Subset of T Helper Cells May Play a Critical Role in Multiple Sclerosis

New Subset of T Helper Cells May Play a Critical Role in Multiple Sclerosis

A study by Wanqiang Sheng and colleagues from the National University of Singapore, published in Cell Research identifies a new subset of T helper (Th) cells that may play a key role in autoimmune neuroinflammatory conditions such as multiple sclerosis. Recent evidence indicates that granulocyte-macrophage colony-stimulating factor (GM-CSF) is a major encephalitogenic factor contributing to […]

The TRPV1 Pain Receptor is Expressed and Functionally Active in Human T Lymphocytes

The TRPV1 Pain Receptor is Expressed and Functionally Active in Human T Lymphocytes

A study published in Nature Immunology reveals a previously unrecognized, ‘non-canonical’ role of the pain TRPV1 receptor – namely, its functional expression, and involvement in TCR signaling and pro-inflammatory activities of T cells. Transient receptor potential vanilloid type 1 ion channel (TRPV1), initially identified as the receptor for capsaicin (the hot ingredient of chilli peppers) […]

IL-17: A Promising Therapeutic Target in Several Chronic Inflammatory Diseases

IL-17: A Promising Therapeutic Target in Several Chronic Inflammatory Diseases

COMMENTARY ARTICLE on the study by Dominique L. P. Baete and Vijay K. Kuchroo Nat Med. 2013 Jul;19(7):824-5 How Cytokine networks fuel inflammation: Interleukin-17 and a tale of two autoimmune diseases Since the discovery of T helper 17 (Th17) cells, an increasing body of evidence indicates that these cells play a major role in the […]

A Hierarchical Cytokines Framework Defining Groups of Chronic Inflammatory Diseases: Learning From Cytokine-Targeted Therapies

A Hierarchical Cytokines Framework Defining Groups of Chronic Inflammatory Diseases: Learning From Cytokine-Targeted Therapies

COMMENTARY ARTICLE on the study by George Schett et al, Nat Med, 2013 Jul;19(7):822-4 How cytokine networks fuel inflammation: Toward a cytokine-based disease taxonomy Extensive genome-wide association and epidemiological studies have shed light on the causes of chronic inflammatory diseases and have confirmed a central role of the immune system and particularly of cytokines [1]. […]

First Report That Interleukin-17A Levels Are Increased In Fibromyalgia Patients

First Report That Interleukin-17A Levels Are Increased In Fibromyalgia Patients

A recent study by Andrei Pernambuco and colleagues from the Federal University of Minas Gerais, Belo Horizonte, MG, Brazil is perhaps the first to document increased plas­ma levels of interleukin (IL)-17A in fibromyalgia (FM) patients. Interleukin-17 and the T helper (Th)-17 cells play a key role in tissue inflammation and host defense and, recently, the […]

Neuroendocrine Immunology of Rheumatic Diseases: A 10-Year Update

Neuroendocrine Immunology of Rheumatic Diseases: A 10-Year Update

In 2001, Drs. Rainer Straub and Maurizio Cutolo, established experts in the field of neuroendocrine immunology of autoimmune and rheumatic diseases, published a large overview on the role of diverse neural and hormonal factors in rheumatoid arthritis. In the last decade, Maurizio Cutolo, president of the European League against Rheumatism (EULAR) has also organized the […]

Leptin Induces Th17 Responses: Relevance to Systemic Lupus Erythematosus

Leptin Induces Th17 Responses: Relevance to Systemic Lupus Erythematosus

A new Cutting Edge article, in the April 2013 issue of the Journal of Immunology, identifies a link between leptin and T helper (Th)17 cells, based on the evidence that leptin was able to promote Th17 responses in human CD4+ T cells and in mice, both in vitro and in vivo, by inducing the transcription […]

Adiponectin potentiates Th1 and Th17 immune responses

Adiponectin potentiates Th1 and Th17 immune responses

A new study published in March 2013 issue of the Journal of Immunology identifies a new immunomodulatory effect of adiponectin (APN) – its ability to activate DCs through PLCγ/JNK/NF-κB-signaling pathways and release of proinflammatory cytokines, and to potentiate Th1 and Th17 immune responses. Adiponectin, the most abundant adipokine, is known for its insulin-sensitizing effects, is […]

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