hormone and autoimmunity

Arthritis Protection By Estrogens: Driving Th17 Cells To Lymph Nodes But Restricting Their Migration to the Joints?

Arthritis Protection By Estrogens: Driving Th17 Cells To Lymph Nodes But Restricting Their Migration to the Joints?

Annica Andersson and colleagues from the Department of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden published in Arthritis Research & Therapy a study indicating that the regulation exerted by estrogens, to the Th17 cell traffic and migration, may play an important role in the well established protective role of female hormones in rheumatoid […]

New Evidence That Testosterone Provides Protection against Arthritis

New Evidence That Testosterone Provides Protection against Arthritis

A recent study by Rebecca Keith and coworkers from the National Jewish Health, Denver, CO, US, published in Arthritis and Rheumatism, provides further experimental evidence that testosterone deficiency might play a role in the development of arthritis. It is well known that sex hormones are involved in the pathogenesis of rheumatoid arthritis (RA). In addition, […]

Neuroendocrine Immunology of Rheumatic Diseases: A 10-Year Update

Neuroendocrine Immunology of Rheumatic Diseases: A 10-Year Update

In 2001, Drs. Rainer Straub and Maurizio Cutolo, established experts in the field of neuroendocrine immunology of autoimmune and rheumatic diseases, published a large overview on the role of diverse neural and hormonal factors in rheumatoid arthritis. In the last decade, Maurizio Cutolo, president of the European League against Rheumatism (EULAR) has also organized the […]

Adiponectin potentiates Th1 and Th17 immune responses

Adiponectin potentiates Th1 and Th17 immune responses

A new study published in March 2013 issue of the Journal of Immunology identifies a new immunomodulatory effect of adiponectin (APN) – its ability to activate DCs through PLCγ/JNK/NF-κB-signaling pathways and release of proinflammatory cytokines, and to potentiate Th1 and Th17 immune responses. Adiponectin, the most abundant adipokine, is known for its insulin-sensitizing effects, is […]

Sex Steroids Hormones and Autoimmune Disease Activity

Sex Steroids Hormones and Autoimmune Disease Activity

Overview article Females display an increased incidence of autoimmune diseases, with a sexual dimorphism in the immune response. The autoimmune diseases involve both genetic and environmental factors and the autoimmune process is characterized by the breakdown of tolerance in subjects with genetic susceptibility, with subsequent target (organ-specific and not) injury, that, in turn, elicits repairing […]

Sex Hormones and Immunoregulation

Sex Hormones and Immunoregulation

Overview article The sexual dimorphism in immune responses in humans is well known; females have more vigorous cellular and humoral immune responses, they are more resistant to many infections, and they suffer a higher incidence of autoimmune diseases as compared with males [reviewed in Reference 1]. Moreover, in women disease expression appears to be affected […]

The Link Between Stress, Emotions and Cytokine-Related Diseases

The Link Between Stress, Emotions and Cytokine-Related Diseases

Overview Article Adaptation is one of the core characteristics of living organisms, wherever it refers to proximate adjustments at individual level to inner or outer events, or to ultimate evolutionary processes at species-level. Biology and medicine have for a long time considered the non-specific symptoms of sickness (i.e. drowsiness, hypophagia, curled-up posture, fever) as signs […]

Regulation of T Helper Cell Function by Extracellular ATP

Regulation of T Helper Cell Function by Extracellular ATP

Overview article During immune responses a tight balance between proinflammatory and regulatory mechanisms is key in order to restore homeostasis and avoid excessive tissue damage. Among many factors modulating inflammation, extracellular nucleotides have emerged as constitutive signals of cell death alerting the immune system. Due to the ubiquitous expression of receptors for nucleotides and their […]

Estrogens and Dendritic Cells

Estrogens and Dendritic Cells

A study published in the Journal of Immunology demonstrates that estrogens may boost innate immunity by enhancing interferon (IFN)-γ production by CD11c(+) cells. In humans, the sex differences or the sexual dimorphism in immune defense is a well-known phenomenon. Females have more vigorous cellular and humoral immune responses, and they are more resistant to infections […]

Pregnancy and Rheumatoid Arthritis

Pregnancy and Rheumatoid Arthritis

Overview article Rheumatoid arthritis (RA) is a systemic, chronic inflammatory disorder, characterized by symmetrical polyarthritis and presence of extra-articular manifestations including subcutaneous nodules, lung disease, pericarditis, hematopoietic disturbances, neuropathy, and vasculitis. RA occurs in 0.5 to 1% of the population with a female to male ratio of 3:1 and with an increasing incidence with advancing […]

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