discovery medicine

New Function for Prolactin: Involvement in Sexual Behavior, Pair-Bonding and Infant Care

New Function for Prolactin: Involvement in Sexual Behavior, Pair-Bonding and Infant Care

Prolactin is well-known for its role in stimulating milk production in nursing mothers but a new study published in the online journal PLoS One identifies a previously unrecognized function of this hormone – its contribution to sexual behavior and pair-bonding. The study used cotton-top tamarins, a socially-monogamous, small monkey native to Colombia that live in […]

First Evidence of Sensory Nerves Driving Interleukin-23 Production in Skin: A Breakthrough in Psoriasis Research?

First Evidence of Sensory Nerves Driving Interleukin-23 Production in Skin: A Breakthrough in Psoriasis Research?

A study published in the June 05, 2014 issue of Nature magazine indicates that sensory nerve-driven interleukin-(IL)-23 production by dermal dendritic cells (DDCs) contributes to psoriasis-like inflammation. These findings may represent a breakthrough in psoriasis research and the understanding of the pathogenesis of this skin disease. The IL-23→IL-17 axis plays a major role in the […]

Bridging Neurosciences and Immunology – An Overview

Bridging Neurosciences and Immunology – An Overview

Historical Perspectives The brain and the immune system, or the “supersystems”, a term coined by Tomio Tada (1997), are the two major adaptive systems of the body. Although the immune system has been often regarded as autonomous, the evidence accumulated over several decades indicates that the central nervous system (CNS) receives messages from the immune […]

The Discovery of Adrenaline

The Discovery of Adrenaline

Historical Perspectives The first practical discovery of adrenaline by man occurred when one of our ancestral hominids while out for a stroll was unexpectedly surprised by a sabre-toothed tiger. Isolating and naming the compound were not uppermost in our man’s mind at the time and it was not until the late nineteenth century that progress […]

The Discovery of Interferon, the First Cytokine, by Alick Isaacs and Jean Lindenmann in 1957

The Discovery of Interferon, the First Cytokine, by Alick Isaacs and Jean Lindenmann in 1957

Historical Perspectives I first met Alick Isaacs in November, 1955. He immediately struck me as an extremely intelligent and very lively person; though little did I know that those next few years would lead to a major discovery – that of interferon – and also that working with him was going to set the course […]