dementia

New Evidence Linking Clusterin and Other Complement Proteins to Alzheimer’s Progression and Prediction

New Evidence Linking Clusterin and Other Complement Proteins to Alzheimer’s Progression and Prediction

A study recently published in the Journal of Alzheimer’s Disease gives hope in the search of Alzheimer’s biomarkers indicating that some complement factors such as clusterin may serve as reliable predictors of Alzheimer’s disease progression. It is well known that inflammation and pro-inflammatory mediators contribute to the pathogenesis of dementia and Alzheimer’s. The complement system, […]

Interleukin-33 Reverses Cognitive Deficits in Alzheimer’s Mouse Model Showing Promise as a Therapeutic Target

Interleukin-33 Reverses Cognitive Deficits in Alzheimer’s Mouse Model Showing Promise as a Therapeutic Target

A new study published in the Proceedings of the National Academy of Sciences USA (PNAS) indicates that interleukin-33 (IL-33) is able to improve memory deficits and reduce the accumulation of β-amyloid in APP/PS1 mice that exhibit Alzheimer’s disease (AD)-like pathologies. IL-33 is a member of the IL-1 cytokine family and is considered an ‘alarm’ molecule […]

New Evidence that Stress May Increase the Risk of Developing Dementia and Alzheimer’s: the Einstein Aging Study

New Evidence that Stress May Increase the Risk of Developing Dementia and Alzheimer’s: the Einstein Aging Study

According to a recent report published in the journal Alzheimer Disease & Associated Disorders stress may increase up to 30% the risk of developing amnestic mild cognitive impairment (aMCI) or dementia. Mild cognitive impairment is a significant risk factor for the development of dementia and Alzheimer’s disease. Moreover, among all MCI subtypes, patients with amnestic […]

Blocking IL-12 and IL-23 in APPPS1 Mouse Model Shows Promise as an Experimental Therapeutic Approach to Alzheimer’s Disease

Blocking IL-12 and IL-23 in APPPS1 Mouse Model Shows Promise as an Experimental Therapeutic Approach to Alzheimer’s Disease

A recent study, published in Nature Medicine is perhaps the first one to show interleukin (IL)-23 involvement, and implicates both IL-23 and IL-12, key pro-inflammatory cytokines in the pathogenesis of Alzheimer’s disease. Importantly, it also demonstrates that in the APPPS1 Alzheimer’s disease mouse model, preventing the effects of these mediators, or ‘immune hormones’, with antibodies […]

Long Term Use of Common Anticholinergic Drugs Linked To High Risk of Dementia

Long Term Use of Common Anticholinergic Drugs Linked To High Risk of Dementia

A new report published in JAMA Internal Medicine (formerly, Archives of Internal Medicine) indicates that cumulative anticholinergic medications exposure and use in the past 10 years is associated with a significantly increased risk for developing dementia. Common anticholinergic drugs include tricyclic antidepressants, first-generation antihistamines, and urinary bladder antispasmodics or some anti-vertigo drugs. In the JAMA […]

Julianne Moore Performing in Alzheimer’s Drama ‘Still Alice’ Wins Hollywood Actress Award

Julianne Moore Performing in Alzheimer’s Drama ‘Still Alice’ Wins Hollywood Actress Award

Among the winners of this year’s Hollywood Film Awards is Julianne Moore – she wins this award for her performance as a linguistics professor with Alzheimer’s disease in the movie ‘Still Alice’. The Richard Glatzer and Wash Westmoreland’s movie is based on the 2007 novel ‘Still Alice’, written by Lisa Genova, an American neuroscientist and […]

Hyperactive Type I Interferon System in the Choroid Plexus Linked To Aging and Cognitive Dysfunction

Hyperactive Type I Interferon System in the Choroid Plexus Linked To Aging and Cognitive Dysfunction

A study published in the August 21, 2014 issue of Science magazine demonstrates that aging is associated with an overactive IFN-I system at a specific brain structure, the choroid plexus. This vascular tissue, found in all cerebral ventricles, is an epithelial monolayer that forms the blood-cerebrospinal fluid barrier, and, in fact, represents the ‘interface’ between […]

Lena Johansson, Stress and Alzheimer’s Risk in Women

Lena Johansson, Stress and Alzheimer’s Risk in Women

SHORT FEATURES and FACES ARTICLE In this recent editorial, Lena Johansson outlines some current concepts and research trends related to the long terms effects of stress and their impact on risk and development of Alzheimer’s disease (AD) in women. Dr. Johansson has authored two population studies – perhaps the first in this area – on […]

A Set of 10 Lipid Biomarkers May Predict Alzheimer’s and Mild Dementia

A Set of 10 Lipid Biomarkers May Predict Alzheimer’s and Mild Dementia

A study published in Nature Medicine indicates that a research team from the Georgetown University, Washington, DC and six other US institutions has identified a blood lipid profile test that can eventually predict the development of mild dementia or Alzheimer’s disease (AD) within three years. In the last 15 years there have been over 100 […]

Drug Companies and NIH in $230 Million Joint Project for Alzheimer’s, Diabetes, Lupus and Arthritis

Drug Companies and NIH in $230 Million Joint Project for Alzheimer’s, Diabetes, Lupus and Arthritis

Along with funding from the United States government and ten large pharmaceutical companies, the National Institutes of Health (NIH), Bethesda, Maryland will split the cost of a new multimillion project targeting common chronic human diseases. The companies involved include Pfizer Inc., Eli Lilly & Co, AbbVie Inc., Biogen Idec Inc., Bristol-Myers Squibb Co., Glaxo Smith […]

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