cytokines

First Evidence that Meningeal Interferon-γ Affects Neuronal Connectivity and Social Behavior

First Evidence that Meningeal Interferon-γ Affects Neuronal Connectivity and Social Behavior

A recent study published in Nature magazine links the meningeal immunity to the regulation of social behavior, implicating the meningeal interferon (IFN)-γ and its modulatory effects on the activity of brain cortex GABAergic neurons. Diseases such as autism spectrum disorder, frontotemporal dementia and schizophrenia are characterized by severe social and immune dysfunction. Little is known […]

2015 Bringing Some Major Advances in Neuroendocrine Immunology

2015 Bringing Some Major Advances in Neuroendocrine Immunology

EDITORIALS & OPINIONS In 2003, the National Institutes of Health (NIH), Bethesda, MD, USA, launched the NIH Roadmap for Medical Research, marking the renaissance in interdisciplinary research, and outlining new perspectives of cutting-edge 21st century work that crosses disciplines. The ‘interdisciplinary research’, as per the Roadmap, was defined as “integrating the analytical strengths of two […]

Interleukin-35 Restrains Lymphocytic Infiltration and T Cell-Dependent Anti-Tumor Immunity

Interleukin-35 Restrains Lymphocytic Infiltration and T Cell-Dependent Anti-Tumor Immunity

A new study published in the journal Immunity indicates that interleukin (IL)-35 inhibits the recruitment of effector anti-tumor T cells and suppresses their function in the tumor microenvironment. IL-35 belongs to the IL-12 family of cytokines. It is a dimeric protein composed of two subunits – p35 and EBI3, which are shared with other IL-12 […]

Cytokines Driving Sympathetic Nervous System Activation in the Subfornical Organ: Implications for Heart Failure and Hypertension

Cytokines Driving Sympathetic Nervous System Activation in the Subfornical Organ: Implications for Heart Failure and Hypertension

A recent study published in Hypertension demonstrates that cytokines such as interleukin (IL)-1β and tumor necrosis factor (TNF)-α acting at the level of the subfornical organ induce the expression of inflammatory and excitatory mediators that subsequently drive sympathetic nervous system activation. The subfornical organ (SFO), a highly vascularized structure is a circumventricular organ that lacks […]

Rejecting Allergens: The Avoidance Behavior

Rejecting Allergens: The Avoidance Behavior

EVOLVING CONCEPTS ARTICLE The immune system can recognize, assimilate or reject self and non-self components. Indeed, immunological activities vary in a spectrum that goes from total tolerance (assimilation of self and non-self) to intolerance (rejection of self and non-self). Immunologists are aware of the power of immunologic rejection of histo-incompatible transplanted organs or tissues as […]

A Mechanism Linking Immune Cells Activities, Biomarkers and Hippocampal Volume Loss to Post-Traumatic Stress Disorder

A Mechanism Linking Immune Cells Activities, Biomarkers and Hippocampal Volume Loss to Post-Traumatic Stress Disorder

In a recent review in Journal of Neurochemistry, James Andrews and Kameran Neises from the Naval Health Research Center, San Diego, California provide up to date information, and a brief but comprehensive overview on how peripheral blood mononuclear cells (PBMCs) and biomarkers may play a role in a putative mechanism and effective diagnosis of PTSD. […]

Aging and Alterated Sympathetic Innervation of Lymphoid Organs in Rodents: Implications

Aging and Alterated Sympathetic Innervation of Lymphoid Organs in Rodents: Implications

A study in Journal of Neuroimmunology suggests that aging is linked to significant alterations in the sympathetic nervous innervation of lymphoid organs that may contribute to aging-related immunosuppression, The sympathetic nervous system (SNS) is a major branch of the autonomic nervous system and the peripheral stress system. The function of the human SNS is altered […]

Thyroxine – an Endogenous Inhibitor of Migration Inhibitory Factor (MIF) Proinflammatory Activity

Thyroxine – an Endogenous Inhibitor of Migration Inhibitory Factor (MIF) Proinflammatory Activity

A new study published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) suggests that thyroxine (T4) is a strong endogenous inhibitor of the migration inhibitory factor (MIF) pro-inflammatory activities. Importantly, the study also indicates that low T4 and high MIF levels may contribute to the lethal systemic […]

Cytokine Profiles in Subjects with Autism Spectrum Disorders

Cytokine Profiles in Subjects with Autism Spectrum Disorders

In a study published in the online journal PLoS ONE, a research group from the Hamamatsu University School of Medicine, Hamamatsu, Japan reports the presence of high levels of several pro-inflammatory cytokines in male (≥6 years old) subjects with autism spectrum disorder (ASD). ASD include autistic disorder, Asperger’s disorder and pervasive developmental disorder. A dysregulation […]

Overview of the ”New Generation” Cytokines

Overview of the ”New Generation” Cytokines

In this review, published in Arthritis Research & Therapy Cem Gabay and Iain McInnes present the biology and relevant pathophysiology of several novel cytokines, with focus on their involvement in rheumatic diseases. This list includes the interleukin (IL)-1 superfamily (IL-18 and IL-33), the IL-12 superfamily (IL-27 and IL-35), the IL-2 superfamily (IL-15 and IL-21), and […]

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