catecholamines

Beta-Adrenoceptors and Tumor Development: Novel Concepts and Clinical Implications

Beta-Adrenoceptors and Tumor Development: Novel Concepts and Clinical Implications

ENVOLVING CONCEPTS ARTICLE Over the last 3 decades, an increasing body of evidence suggests that catecholamine-dependent signalling may represent a major link between chronic stress and tumor progression. Studies addressing the relationship between stress-activated pathways and cancer progression suggest that stress-induced production of adrenaline and noradrenaline, besides affecting the anti-tumor immune response also displays direct […]

New Evidence that Catecholamines Increase Enterovirus 71 Infectivity

New Evidence that Catecholamines Increase Enterovirus 71 Infectivity

COMMENTARY ARTICLE on the study by Liao YT et al. PLoS One, 10(8):e0135154. doi: 10.1371/journal.pone.0135154. Norepinephrine and Epinephrine Enhanced the Infectivity of Enterovirus 71 Outbreaks of Human Enterovirus 71 (EV71) are often reported in Asia. EV71 is responsible for syndromes like hand-foot and mouth disease, but is also involved in pulmonary edema (PE) and in […]

Stress promotes tumor growth by amplifying the cancer cells’ ability to evade apoptosis

Stress promotes tumor growth by amplifying the cancer cells’ ability to evade apoptosis

A study published in the Journal of Clinical Investigation indicates that stress or the stress hormone adrenaline, through stimulation of beta-adrenoreceptors (ADRs), activate signaling pathways that lead to the inhibition of apoptosis. This enables prostate cancer cells to evade apoptosis, which is an important feature of tumor growth and metastasis. An increasing body of evidence […]

Richard Kvetnansky – 45 years of Stress Research

Richard Kvetnansky – 45 years of Stress Research

SHORT FEATURES and FACES ARTICLE Richard Kvetnansky, M.D., is the head of the Laboratory of Stress Research at the Institute of Experimental Endocrinology, Slovak Academy of Sciences in Bratislava, Slovakia. He was a director of the Institute for eight years. Dr. Kvetnansky, an experimental endocrinologist, has performed seminal work in the field of the sympathoadrenal […]

Biobehavioral Factors, Stress and Cancer Progression: A Contemporary Review

Biobehavioral Factors, Stress and Cancer Progression: A Contemporary Review

In two recent reviews, published in 2011, Erin Costanzo, Anil Sood and Susan Lutgendorf provide a contemporary overview of the major pathways involved in the cross-talk between behavioral factors and the immune system that contribute to cancer development  and progression. The idea that psychological factors may contribute to cancer development and progression is not new. […]

Developmental Changes in the Neuroendocrine/Stress-Immune Interactions: Immunosenescence and Infectious/Inflammatory Disease Risk in the Elderly

Developmental Changes in the Neuroendocrine/Stress-Immune Interactions: Immunosenescence and Infectious/Inflammatory Disease Risk in the Elderly

In a recent review, Kathi Heffner from the Department of Psychiatry, University of Rochester Medical Center, Rochester, New York outlines recent data suggesting that immunosenescence, endocrinosenescence and age-related dysregulation of stress response systems are closely intertwined. Immunosenescence refers to the dysfunction and gradual deterioration of the immune system associated with aging. This overall change in […]

First Evidence That Stress and Epinephrine Promote Leukemia Progression

First Evidence That Stress and Epinephrine Promote Leukemia Progression

In a recent PLoS One study, perhaps the first in the area of hematological tumors, and specifically leukemia, Shelly Inbar and colleagues from the Neuroimmunology Research Unit, Department of Psychology, Tel Aviv University, Israel, demonstrate marked adverse effects of stress hormones and prostaglandin E2 (PGE2) on survival rates of leukemic animals. An increasing body of […]

Hypothalamic-Pituitary-Adrenal Axis Function in Rheumatoid Arthritis

Hypothalamic-Pituitary-Adrenal Axis Function in Rheumatoid Arthritis

OVERVIEW ARTICLE The neuroendocrine and the immune system are important homeostatic mechanisms maintaining the integrity of the organism. The efficacy of these homeostats in dynamic internal and external environments is a basis for successful adaptation to endogenous and exogenous stimuli that the organism constantly encounters. The adaptive reactions are complex and their ‘self-protecting’ nature serves […]