catecholamines sympathetic innervation and immunity immune system

The Central Inflammatory Reflex: Afferent Vagal and Central Brain Stimulations Control Experimental Arthritis

The Central Inflammatory Reflex: Afferent Vagal and Central Brain Stimulations Control Experimental Arthritis

PhD THESIS SYNOPSIS Inflammation is a protective and complex biological response to harmful stimuli, such as infection and tissue damage, that involves cell infiltration and production of inflammatory cytokines. Rheumatoid Arthritis (RA) is the most common type of inflammatory autoimmune disease affecting over 1.5 million adult Americans. It is characterized by chronic inflammation of synovial […]

Activation of the Brain-Splenic Nerve Axis in Hypertension: The Cholinergic-Sympathetic-Immune System Connection

Activation of the Brain-Splenic Nerve Axis in Hypertension: The Cholinergic-Sympathetic-Immune System Connection

A recent Nature Communications study indicates that hypertension is linked to T cell activation and an egression of T-cells from the spleen, and that this process is dependent on a vagus-splenic nerve connection. Hypertension is a major risk factor for coronary heart diseases and stroke. Despite various therapeutic approaches 10-15% of the general hypertensive population […]

β2-Adrenergic Receptor Activation Promotes M2 Polarization of Gut Macrophages: How the Brain–Gut Axis Maintains Tissue Homeostasis

β2-Adrenergic Receptor Activation Promotes M2 Polarization of Gut Macrophages: How the Brain–Gut Axis Maintains Tissue Homeostasis

Commentary on the study by Ilana Gabanyi et al, Cell, 2016 164, 378-391 Neuro-Immune Interactions Drive Tissue Programming in Intestinal Macrophages A new study published in the journal Cell indicates that tissue macrophages located in different regions of the gut, exhibit a high degree of specialization and form a cellular network with enteric neurons. The […]

Influence of the Sympathetic Nervous System on Regulatory T cells: Another Link in Neuro-Immune Interactions

Influence of the Sympathetic Nervous System on Regulatory T cells: Another Link in Neuro-Immune Interactions

Overview article Homeostatic control of the immune system is dependent on CD4, FoxP3+, NKT or antigen-specific CD4+ or CD8+ regulatory T cells. These regulatory T cells are essential to prevent or mitigate autoimmunity and the immune response to non-self antigens. Herein is an overview of our observations on the inhibition of the induction of splenic […]