catecholamines and immune cells

Norepinephrine May Shift the IL-12/IL-23 Ratio of Dendritic Cells towards IL-23 Predominance thus Favoring Th17 Differentiation

Norepinephrine May Shift the IL-12/IL-23 Ratio of Dendritic Cells towards IL-23 Predominance thus Favoring Th17 Differentiation

A new study published in the January 15, 2016 issue of the Journal of Immunology indicates that in murine bone marrow–derived dendritic cells (DCs), norepinephrine, via stimulation of β2-adrenoceptors, is able to promote a shift in the IL-12p70/IL-23 cytokine ratio. Primary and secondary lymphoid organs receive a rich autonomic nervous system innervation, mainly by the […]

Cool Housing Temperature and Cold Stress Linked To Immunosuppression and Increased Tumor Growth in Experimental Animals

Cool Housing Temperature and Cold Stress Linked To Immunosuppression and Increased Tumor Growth in Experimental Animals

In the December 2013 issue of the Proceedings of the National Academy of Sciences of the USA Kathleen Kokolus et al., from the Roswell Park Cancer Institute, Buffalo, NY and the US Environmental Protection Agency, NC, demonstrate that a cool ambient housing temperature may affect the outcome of a broad range of experimental endpoints, including […]

Beta Adrenoreceptor – Src Kinase Signaling As a Trigger for Cancer Metastasis

Beta Adrenoreceptor – Src Kinase Signaling As a Trigger for Cancer Metastasis

In the July 2013 issue of Nature Communications, Armaiz-Pena et al. demonstrate that stress is able through activation of beta-adrenergic signaling in tumor cells to trigger a critical phosphorylation event, resulting in Src kinase activation, which in turn, can affect tumor growth and metastasis. Building on previous work showing that sympathetic nervous system activity can […]

Endogenous Catecholamines in Immune Cells: Discovery, Functions And Clinical Potential as Therapeutic Targets

Endogenous Catecholamines in Immune Cells: Discovery, Functions And Clinical Potential as Therapeutic Targets

OVERVIEW ARTICLE The catecholamines dopamine, noradrenaline and adrenaline are well established neurotransmitters and neurohormones. Sympathoadrenergic pathways are pivotal to the communication between the nervous system and the immune system, and the role of dopaminergic pathways in the modulation of immune response is being increasingly unveiled. However, over the last two decades, evidence has accumulated regarding […]

Cold-Induced Stress May Promote Chlamydia Genital Infection

Cold-Induced Stress May Promote Chlamydia Genital Infection

A recent study by Tesfaye Belay and Anthony Woart from the School of Arts and Sciences, Bluefield State College, Bluefield, WV, is perhaps the first to document a link between cold (weather) stress and the course of Chlamydia trachomatis infection. This common sexually transmitted infection is known to cause severe complications such as pelvic inflammatory […]

Sympathetic neural control of circadian oscillations in leukocyte migration

Sympathetic neural control of circadian oscillations in leukocyte migration

In the August 2012 issue of Immunity, Scheiermann et al. describe a series of experiments that elegantly illustrate the patterns of leukocyte homing to the bone marrow and recruitment to skeletal muscle, and how they are affected by photic and adrenergic input. Scheiermann et al. begin by establishing that circadian oscillations are present in peripheral […]

Aging Alters Sympathetic Noradrenergic Innervation and Immune Reactivity in the Lymphoid Organs: Strategies to Reverse Neuro-Immune Senescence

Aging Alters Sympathetic Noradrenergic Innervation and Immune Reactivity in the Lymphoid Organs: Strategies to Reverse Neuro-Immune Senescence

OVERVIEW ARTICLE Current therapeutic strategies in medicine emphasize the influence of “mind” over “body” in the maintenance of health and development, progression, and recovery from diseases. This is achieved by interactions between the nervous system, endocrine system, and immune system in controlling health and disease mediated through various psychological, emotional, and spiritual factors. Several studies […]

Autonomic Nervous System Shift Linked to Infections following Acute Intracerebral Hemorrhage

Autonomic Nervous System Shift Linked to Infections following Acute Intracerebral Hemorrhage

A report in the journal Stroke indicates that a sympathetic nervous system over-activity and predominance is associated with higher rate of infection following acute intracerebral hemorrhage (ICH). Stroke is a major cause of morbidity and the third leading cause of death in the Western world. Infections occur commonly following stroke and adversely influence outcome. Pulmonary […]

Aging and Alterated Sympathetic Innervation of Lymphoid Organs in Rodents: Implications

Aging and Alterated Sympathetic Innervation of Lymphoid Organs in Rodents: Implications

A study in Journal of Neuroimmunology suggests that aging is linked to significant alterations in the sympathetic nervous innervation of lymphoid organs that may contribute to aging-related immunosuppression, The sympathetic nervous system (SNS) is a major branch of the autonomic nervous system and the peripheral stress system. The function of the human SNS is altered […]

Dysfunctional Sympathetic-Immune Interface in Disease States of the Gastrointestinal Tract

Dysfunctional Sympathetic-Immune Interface in Disease States of the Gastrointestinal Tract

OVERVIEW ARTICLE The sympathetic nervous system (SNS) is an integrative interface between the central nervous system and viscera that contributes to the maintenance of homeostasis. It is comprised of cholinergic preganglionic sympathetic neurons which innervate postganglionic sympathetic neurons (PGSNs) and adrenal chromaffin cells (ACCs). Catecholamines and sympathetic co-transmitters, including adenosine triphosphate (ATP), or a related […]

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