brain and immune system

The Discovery of the Brain Lymphatic System

The Discovery of the Brain Lymphatic System

COMMENTARY ARTICLE on the study by Antoine Louveau et al., Nature, 2015, 523:337-41 Structural and functional features of central nervous system lymphatic vessels Until recently, the concept that the brain is an ‘immune privileged’ organ was widely accepted. This concept was built from two main morphological concepts, 1) the impenetrability of the blood brain barrier […]

Neuroendocrine Immunology in 2014 – What Was Hot and Some Conceptual Trends as Presented on BrainImmune

Neuroendocrine Immunology in 2014 – What Was Hot and Some Conceptual Trends as Presented on BrainImmune

EDITORIALS & OPINIONS In 2014 we witnessed a rapid growth of the research and studies at the interface and intersection of neurosciences and immunology. This vast interdisciplinary area, often referred to as neuroendocrine immunology or neuroimmunology, also includes stress-immune interactions that may have complex and multifaceted impact on health and disease. Last year also brought […]

Endogenous Catecholamines in Immune Cells: Discovery, Functions And Clinical Potential as Therapeutic Targets

Endogenous Catecholamines in Immune Cells: Discovery, Functions And Clinical Potential as Therapeutic Targets

OVERVIEW ARTICLE The catecholamines dopamine, noradrenaline and adrenaline are well established neurotransmitters and neurohormones. Sympathoadrenergic pathways are pivotal to the communication between the nervous system and the immune system, and the role of dopaminergic pathways in the modulation of immune response is being increasingly unveiled. However, over the last two decades, evidence has accumulated regarding […]

Neuroendocrine-Immune Interactions in Lung Inflammatory Diseases

Neuroendocrine-Immune Interactions in Lung Inflammatory Diseases

OVERVIEW ARTICLE Inflammation is the body’s response to insults. During inflammation, various inflammatory cells are activated to release cytokines and mediators and orchestrate progressing inflammation. Clinically, pneumonia and acute respiratory distress syndrome involve acute inflammation, whereas asthma and chronic obstructive pulmonary diseases represent chronic inflammation. Inflammation is regulated by both the immune and neuroendocrine systems. […]

Brain-Immune Signaling: Focus on Pathogen Recognition and PGE2 Synthesis

Brain-Immune Signaling: Focus on Pathogen Recognition and PGE2 Synthesis

OVERVIEW ARTICLE The body’s reaction to infections involves the orchestration of multiple systems to effectively initiate, execute and resolve the immune response. At the core of these adaptive processes are the cellular and molecular neural, immune and endocrine interactions that begin with the central nervous system recognizing the presence of an infection. The mediator prostaglandin […]

Nerve Growth Factor and Inflammation: A Complex Bidirectional Interaction

Nerve Growth Factor and Inflammation: A Complex Bidirectional Interaction

OVERVIEW ARTICLE The nervous and immune systems share common functions: both are involved in adapting the body to the environment and in maintaining homeostasis. Because they are the two major adaptive systems of the body it is not surprising that they have developed common strategies: both are able to sense external and internal variations, which […]

Role of the Vagus Nerve at the Neural-Immune Interface

Role of the Vagus Nerve at the Neural-Immune Interface

OVERVIEW ARTICLE Evidence shows that the central nervous system monitors and modulates the activity of both circulating and tissue immune cells via the neuroendocrine system and autonomic nerves. Furthermore, findings over the last decade have demonstrated that the vagus nerve represents an important bi-directional link between the brain and immune system. Afferent vagal pathways transmit […]

Bridging Neurosciences and Immunology – An Overview

Bridging Neurosciences and Immunology – An Overview

HISTORY OVERVIEWS The brain and the immune system, or the “supersystems”, a term coined by Tomio Tada (1997), are the two major adaptive systems of the body. Although the immune system has been often regarded as autonomous, the evidence accumulated over several decades indicates that the central nervous system (CNS) receives messages from the immune […]

Mainstream Immunology Research and Cultural Separation

Mainstream Immunology Research and Cultural Separation

EDITORIALS & OPINIONS One of the curious aspects of modern biomedicine is the “cultural separation” of immunology research from neurobiology and physiology research. One can argue that the failure to link the immune system to the brain (and vice versa) has played a role in the immunology’s minimal progress from the bench to the bedside […]