beta adrenergic receptor

Beta-Adrenoceptors and Tumor Development: Novel Concepts and Clinical Implications

Beta-Adrenoceptors and Tumor Development: Novel Concepts and Clinical Implications

Evolving Concepts Over the last 3 decades, an increasing body of evidence suggests that catecholamine-dependent signalling may represent a major link between chronic stress and tumor progression. Studies addressing the relationship between stress-activated pathways and cancer progression suggest that stress-induced production of adrenaline and noradrenaline, besides affecting the anti-tumor immune response also displays direct tumor-promoting […]

Sympathetic Nerves via β2-adrenoceptor Signaling Generate Circadian Rhythms and Govern Lymphocyte Recirculation in Lymph Nodes

Sympathetic Nerves via β2-adrenoceptor Signaling Generate Circadian Rhythms and Govern Lymphocyte Recirculation in Lymph Nodes

A new study, published in the Journal of Experimental Medicine (JEM), indicates that in mice, the sympathetic nervous system (SNS) innervation, through β2-adrenergic receptors activation controls the circadian dynamics and traffic of lymphocytes through the lymph nodes (LNs). Both primary and secondary lymphoid organs are heavily innervated, mostly by the peripheral sympathetic nerves. Thus, locally […]

Stress-Induced β2-Adrenoceptor-Mediated M2 Macrophage Polarization Promoting Tumor Growth in a Mouse Model of Breast Cancer

Stress-Induced β2-Adrenoceptor-Mediated M2 Macrophage Polarization Promoting Tumor Growth in a Mouse Model of Breast Cancer

A new study published in the BMB Reports indicates that stress hormones such as epinephrine (adrenaline) may promote the transformation of M1-type macrophages to M2-type macrophages and, thus, accelerate tumor growth in a mouse model of breast cancer. Several studies have linked psychological stress and breast cancer risk, associating with the involvement of stress mediators […]

Psychological Stress May Promote Inflammation through Expansion of Immature Proinflammatory Monocytes

Psychological Stress May Promote Inflammation through Expansion of Immature Proinflammatory Monocytes

A recent study by Nicole Powell et al. published in the October 8, 2013 issue of PNAS, suggests that stress hormones may contribute to pro-inflammation through selective expansion and/or recruitment of a specific subpopulation of immature, proinflammatory monocytes. In the 1970s and 1980s stress was often considered immunosuppressive. Recent evidence, however, indicates that psychological stress […]

Beta Adrenoreceptor – Src Kinase Signaling As a Trigger for Cancer Metastasis

Beta Adrenoreceptor – Src Kinase Signaling As a Trigger for Cancer Metastasis

In the July 2013 issue of Nature Communications, Armaiz-Pena et al. demonstrate that stress is able through activation of beta-adrenergic signaling in tumor cells to trigger a critical phosphorylation event, resulting in Src kinase activation, which in turn, can affect tumor growth and metastasis. Building on previous work showing that sympathetic nervous system activity can […]

Activation of Beta2-Adrenoreceptors Drives T Helper Cell Priming In Favor of IL-17 Responses

Activation of Beta2-Adrenoreceptors Drives T Helper Cell Priming In Favor of IL-17 Responses

In a recent study published in the journal Cytokine, Michela Manni, Richard Granstein and Georges Maestroni, from the Center for Experimental Pathology, Locarno, Switzerland, provide new evidence suggesting that catecholamines, through activation of beta2-adrenoreceptors (ARs) on immune cells, may drive, in certain conditions, Th17 immune responses. The authors report that the beta2-AR agonist salbutamol is […]