autoimmunity

Brain Superautoantigens: Connections between Immune and Neural Repertoires

Brain Superautoantigens: Connections between Immune and Neural Repertoires

Opinion Article Introduction Although human cells express a quasi-infinite number of potential autoantigens, only a limited range of the human “self” antigen library is actually targeted by pathological autoimmunity. Accordingly, the clinical expression of human autoimmunity is essentially restricted to relatively few stereotyped disorders including psoriasis, diabetes, vitiligo, thyroiditis, rheumatoid arthritis and multiple sclerosis. Thus, […]

New Evidence that Th17 Cells Contribute to Hashimoto’s Thyroiditis

New Evidence that Th17 Cells Contribute to Hashimoto’s Thyroiditis

Commentary On the study by K Degertekin et al, Cytokine, 2016, 80:13-7 Circulating Th17 cytokine levels are altered in Hashimoto’s thyroiditis The T helper (Th)1/Th2 paradigm has been used to explain many aspects of immune physiology and several immune-associated pathological conditions. Recent progress in the field has prompted increased focus on other effector T lymphocytes […]

Novel TRAIL+ NK Cell Subset May Restrain Autoreactivity in Viral Infections: Implications For Sjogren’s Disease and Virus-Induced Autoimmunity

Novel TRAIL+ NK Cell Subset May Restrain Autoreactivity in Viral Infections: Implications For Sjogren’s Disease and Virus-Induced Autoimmunity

A new study published in the journal Immunity reveals a new role of TRAIL-expressing NK cells during chronic viral infection that may provide further insights into the link between viruses and autoimmune disease development. The TNF-related apoptosis-inducing ligand (TRAIL/Apo2L) is known to induce apoptosis and selective toxicity for cancer cells. However, TRAIL also inhibits autoimmune […]