autoimmunity and stress

Stress & Organ Specific Autoimmunity: A Complex Interrelationship

Stress & Organ Specific Autoimmunity: A Complex Interrelationship

Overview Article The evidence for stress contributing to the onset and course of autoimmune disease is circumstantial and the mechanisms by which stress affects autoimmune disease remain poorly understood. The best evidence for an effect of stress on the development of an autoimmune disorder is the well-known relationship between the clinical onset of Graves’ hyperthyroidism, […]

Stress-Induced Th2 Shift & Thyroid Autoimmunity: Unifying Hypothesis

Stress-Induced Th2 Shift & Thyroid Autoimmunity: Unifying Hypothesis

Evolving Concepts Thyroid autoimmunity may manifest clinically as chronic autoimmune or Hashimoto’s thyroiditis (HT) and its variants (postpartum/sporadic thyroiditis) or as Graves’ disease (GD) and atrophic thyroiditis. These autoimmune thyroid diseases (AITD) occur as a result of aberrant immune response against thyroid antigens due to breakdown of self-tolerance [1]. Although HT and GD share a […]

The Link Between Stress, Emotions and Cytokine-Related Diseases

The Link Between Stress, Emotions and Cytokine-Related Diseases

Overview Article Adaptation is one of the core characteristics of living organisms, wherever it refers to proximate adjustments at individual level to inner or outer events, or to ultimate evolutionary processes at species-level. Biology and medicine have for a long time considered the non-specific symptoms of sickness (i.e. drowsiness, hypophagia, curled-up posture, fever) as signs […]