autoimmune diseases

Donna Jackson Nakazawa and Childhood Disrupted: How Your Biography Becomes Your Biology and How You Can Heal

Donna Jackson Nakazawa and Childhood Disrupted: How Your Biography Becomes Your Biology and How You Can Heal

SHORT FEATURES and FACES ARTICLE What doesn’t kill you makes you stronger? Not quite. Far more often, the opposite is true. Over the past decade, a group of doctors and scientists has discovered that childhood trauma leads to lifelong struggles with mental and physical health. Early chronic stressors shape our biology in ways that pre-determine […]

Inhibitors of RORγt Targeting Th17 Cells May Hold Promising Therapeutic Potential in Inflammation & Autoimmunity

Inhibitors of RORγt Targeting Th17 Cells May Hold Promising Therapeutic Potential in Inflammation & Autoimmunity

Recently, several RORγt inhibitors have been identified that effectively restrict the function and differentiation of pro-inflammatory T helper (Th)17 cells. The transcription factor RORγt belongs to the nuclear receptor superfamily – consisting of 48 members that serve as ligand-activated transcription factors translating extracellular or intracellular signals into a transcriptional response. RORγt is the immune cell-specific […]

Rainer Straub and the Origin of Chronic Inflammatory Systemic Diseases

Rainer Straub and the Origin of Chronic Inflammatory Systemic Diseases

SHORT FEATURES and FACES ARTICLE Synopsis of the Book The Origin of Chronic Inflammatory Systemic Diseases and Their Sequelae by Rainer H Straub Academic Press/Elsevier Chronic inflammatory systemic diseases (CIDs) are a burden to humans because approximately 10% of the population is affected by long-standing chronic inflammatory illness. The numbers would be extensively higher if […]

Novel TRAIL+ NK Cell Subset May Restrain Autoreactivity in Viral Infections: Implications For Sjogren’s Disease and Virus-Induced Autoimmunity

Novel TRAIL+ NK Cell Subset May Restrain Autoreactivity in Viral Infections: Implications For Sjogren’s Disease and Virus-Induced Autoimmunity

A new study published in the journal Immunity reveals a new role of TRAIL-expressing NK cells during chronic viral infection that may provide further insights into the link between viruses and autoimmune disease development. The TNF-related apoptosis-inducing ligand (TRAIL/Apo2L) is known to induce apoptosis and selective toxicity for cancer cells. However, TRAIL also inhibits autoimmune […]

IL-17: A Promising Therapeutic Target in Several Chronic Inflammatory Diseases

IL-17: A Promising Therapeutic Target in Several Chronic Inflammatory Diseases

COMMENTARY ARTICLE on the study by Dominique L. P. Baete and Vijay K. Kuchroo Nat Med. 2013 Jul;19(7):824-5 How Cytokine networks fuel inflammation: Interleukin-17 and a tale of two autoimmune diseases Since the discovery of T helper 17 (Th17) cells, an increasing body of evidence indicates that these cells play a major role in the […]

A Hierarchical Cytokines Framework Defining Groups of Chronic Inflammatory Diseases: Learning From Cytokine-Targeted Therapies

A Hierarchical Cytokines Framework Defining Groups of Chronic Inflammatory Diseases: Learning From Cytokine-Targeted Therapies

COMMENTARY ARTICLE on the study by George Schett et al, Nat Med, 2013 Jul;19(7):822-4 How cytokine networks fuel inflammation: Toward a cytokine-based disease taxonomy Extensive genome-wide association and epidemiological studies have shed light on the causes of chronic inflammatory diseases and have confirmed a central role of the immune system and particularly of cytokines [1]. […]

GrahamRook.net

GrahamRook.net

Dr. Graham Rook is Emeritus Professor of Medical Microbiology at University College London. His website, contains a discussion of the evolutionary theory and immunological mechanisms behind the Old Friends mechanism, a reformulation of the hygiene hypothesis; the implications of faulty immunoregulation for psychiatry, and in particular for depression and stress resilience, and/or autoimmunity and cancer.  Read […]

An Enterovirus Attacking the Thymus May Play a Key Role in Triggering Type 1 Diabetes

An Enterovirus Attacking the Thymus May Play a Key Role in Triggering Type 1 Diabetes

As part of the European FP6 Eurothymaide project, and, in close collaboration with Lille’s CHRU hospital (Didier Hober), the Centre d’Immunologie de Marseille-Luminy (Philippe Naquet) and the University of Tunis, Vincent Geenen and his team have discovered that infection of the thymus by the diabetogenic CV-B4 virus leads to a decrease in the transcription of […]

1,25-Dihydroxyvitamin D3 Transcriptional Repression of Interleukin-17A Expression and Th17-Related Autoimmunity

1,25-Dihydroxyvitamin D3 Transcriptional Repression of Interleukin-17A Expression and Th17-Related Autoimmunity

In a new Molecular and Cellular Biology study, Sneha Joshi and colleagues from the University of Medicine and Dentistry of New Jersey, Newark demonstrate that the reversal of paralysis in EAE mice by 1,25-Dihydroxyvitamin D3 correlates with reduced IL-17A-secreting CD4+ T cells, and that the mechanism involved in 1,25-Dihydroxyvitamin D3-mediated suppression of IL-17A induction involves […]

Evolutionary Medicine, Energy Regulation and the Pathogenesis of Systemic Chronic Inflammatory Diseases

Evolutionary Medicine, Energy Regulation and the Pathogenesis of Systemic Chronic Inflammatory Diseases

EVOLVING CONCEPTS ARTICLE The general meaning of the systemic response in inflammatory diseases is not well understood. Nor do we know whether the systemic response has any unfavorable role when inflammatory diseases become chronic. We call chronic inflammatory diseases (CIDs) “systemic in nature”, but the significance of these systemic signs and symptoms is not known. […]

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