anxiety

Generalized Anxiety Disorder Linked to High IFN-γ and TNF-α but Low IL-10 Peripheral Levels

Generalized Anxiety Disorder Linked to High IFN-γ and TNF-α but Low IL-10 Peripheral Levels

A recent Brain, Behavior, and Immunity study provides perhaps the first evidence that Generalized Anxiety Disorder (GAD) is associated with a peripheral imbalance of pro- versus anti- inflammatory cytokines such as interferon (IFN)-γ, tumor necrosis factor (TNF)-α and interleukin (IL)-10. GAD, classified since the 1980s in the Diagnostic and Statistical Manual of Mental Disorder is […]

New Evidence Indicates that Oxytocin Deficiency May Represent a Biomarker of Anxiety in Children

New Evidence Indicates that Oxytocin Deficiency May Represent a Biomarker of Anxiety in Children

A study by Karen Parker and her research team from the Stanford University School of Medicine links low levels of oxytocin with anxiety in children. Recent evidence indicates that oxytocin is an anxiolytic hormone, as it decreases the release of stress hormones, while oxytocin imbalances have been associated with both anxiety (HJ Lee et al., […]

How to Keep Your Brain Innovative

How to Keep Your Brain Innovative

In a recent article at Inc.com Geil Browning, PhD, Founder and CEO, Emergenetics International, outlines some key principles to keep your brain innovative. The problem with being “crazy busy” is that it does not allow freewheeling thought. Tim Kreider wrote recently in The New York Times that there is a default response when you ask […]

Oxytocin & vasopressin and human emotional and behavioral systems

Oxytocin & vasopressin and human emotional and behavioral systems

A study, published on June 12, 2012, in PLoS One, provides perhaps the first evidence that oxytocin and arginine vasopressin are both dysregulated in Williams Syndrome. Human emotion and social behavior are linked to neuroendocrine function, and two hypothalamic neuropeptides, oxytocin (OT) and arginine vasopressin (AVP) appear to regulate reproduction, social behaviors and emotionality in […]

Negative and Competitive Interpersonal Stressors Linked to High Proinflammatory Cytokine Responses

Negative and Competitive Interpersonal Stressors Linked to High Proinflammatory Cytokine Responses

In a recent PNAS study, Jessica Chiang and colleagues from the Department of Psychology, David Geffen School of Medicine, University of California, Los Angeles, investigated the potential importance of negative, competitive and positive daily interactions on inflammatory activity. The authors of this study demonstrate that negative social interactions significantly predicted higher baseline levels of sTNFaRII […]

Oxytocin Increases Generosity and Charitable Donations

Oxytocin Increases Generosity and Charitable Donations

Some of the prosocial effects of oxytocin (OT) such as trust, emotional empathy and socially reinforced learning are well-known, but a recent study published in the Hormones and Behavior journal is perhaps the first one to show that OT also increases generosity. Oxytocin (OT) is a nine amino acid neuropeptide, discovered by Sir Henry Dale […]

Stress, Immunity and Coronary Artery Disease

Stress, Immunity and Coronary Artery Disease

In this review Roger Ho and colleagues discuss how stress hormones through affecting different components of the immune/inflammatory reaction may in turn contribute to the development of coronary artery disease (CAD). Recent evidence indicates that acute and chronic psychological stress, such as intense anger, low socioeconomic status, work stress, social isolation, depression, anxiety and hostility […]

Substance P Promotes Th17 Phenotype in Generalized Anxiety Disorder

Substance P Promotes Th17 Phenotype in Generalized Anxiety Disorder

A study published in the journal of Clinical Immunology demonstrates that the cytokine profiles in generalized anxiety disorder (GAD) individuals show traits of Th1 and Th2 deficiencies but are associated with a predominant Th17 phenotype, particularly in the presence of substance P (SP). Substance P has been shown to stimulate the inflammatory response, contributing to […]