aging

Sex and Stem cells

Sex and Stem cells

A new study in Cell Stem Cell, discusses the “sexual dimorphism of longevity”, wherein most of supercentenarians are female, linking this to increased stem cell self-renewal and regeneration potential in females. Of note, out of the 53 living supercentenarians – human individuals currently living over the age of 110 – 51 are female, and sexual […]

Blocking IL-12 and IL-23 in APPPS1 Mouse Model Shows Promise as an Experimental Therapeutic Approach to Alzheimer’s Disease

Blocking IL-12 and IL-23 in APPPS1 Mouse Model Shows Promise as an Experimental Therapeutic Approach to Alzheimer’s Disease

A recent study, published in Nature Medicine is perhaps the first one to show interleukin (IL)-23 involvement, and implicates both IL-23 and IL-12, key pro-inflammatory cytokines in the pathogenesis of Alzheimer’s disease. Importantly, it also demonstrates that in the APPPS1 Alzheimer’s disease mouse model, preventing the effects of these mediators, or ‘immune hormones’, with antibodies […]

Long Term Use of Common Anticholinergic Drugs Linked To High Risk of Dementia

Long Term Use of Common Anticholinergic Drugs Linked To High Risk of Dementia

A new report published in JAMA Internal Medicine (formerly, Archives of Internal Medicine) indicates that cumulative anticholinergic medications exposure and use in the past 10 years is associated with a significantly increased risk for developing dementia. Common anticholinergic drugs include tricyclic antidepressants, first-generation antihistamines, and urinary bladder antispasmodics or some anti-vertigo drugs. In the JAMA […]

Sarcopenia, the Skeletal Muscle as an Endocrine Organ and Aging

Sarcopenia, the Skeletal Muscle as an Endocrine Organ and Aging

In a recent review, Drs. A. Pratesi, F. Tarantini and M. Di Bari discuss major hormonal and immune mechanisms that drive the age-related decline in muscle quantity and quality. Besides the hormonal factors, the authors outline the role of some skeletal muscles mediators, termed ‘myokines’ that act in an autocrine, paracrine, or ‘hormone-like’ fashion. This […]

Aging Alters Sympathetic Noradrenergic Innervation and Immune Reactivity in the Lymphoid Organs: Strategies to Reverse Neuro-Immune Senescence

Aging Alters Sympathetic Noradrenergic Innervation and Immune Reactivity in the Lymphoid Organs: Strategies to Reverse Neuro-Immune Senescence

OVERVIEW ARTICLE Current therapeutic strategies in medicine emphasize the influence of “mind” over “body” in the maintenance of health and development, progression, and recovery from diseases. This is achieved by interactions between the nervous system, endocrine system, and immune system in controlling health and disease mediated through various psychological, emotional, and spiritual factors. Several studies […]

Developmental Changes in the Neuroendocrine/Stress-Immune Interactions: Immunosenescence and Infectious/Inflammatory Disease Risk in the Elderly

Developmental Changes in the Neuroendocrine/Stress-Immune Interactions: Immunosenescence and Infectious/Inflammatory Disease Risk in the Elderly

In a recent review, Kathi Heffner from the Department of Psychiatry, University of Rochester Medical Center, Rochester, New York outlines recent data suggesting that immunosenescence, endocrinosenescence and age-related dysregulation of stress response systems are closely intertwined. Immunosenescence refers to the dysfunction and gradual deterioration of the immune system associated with aging. This overall change in […]

Aging and Alterated Sympathetic Innervation of Lymphoid Organs in Rodents: Implications

Aging and Alterated Sympathetic Innervation of Lymphoid Organs in Rodents: Implications

A study in Journal of Neuroimmunology suggests that aging is linked to significant alterations in the sympathetic nervous innervation of lymphoid organs that may contribute to aging-related immunosuppression, The sympathetic nervous system (SNS) is a major branch of the autonomic nervous system and the peripheral stress system. The function of the human SNS is altered […]

Tumor Necrosis Factor – a Possible Link Between Age-Related Endocrine Dyscrasia and Alzheimer’s Disease

Tumor Necrosis Factor – a Possible Link Between Age-Related Endocrine Dyscrasia and Alzheimer’s Disease

In a commentary recently published in the Journal of Alzheimer’s Disease, Ian Clark and Craig Atwood discussed some novel mechanisms and viewpoints related to the “cross-talk” between tumor necrosis factor (TNF) and endocrine dyscrasia, and how this might affect the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD), stroke and traumatic brain disease. Endocrine dyscrasia […]