adrenaline

David Goldstein, Adrenaline, the Inner World and the Scientific Integrative Medicine

David Goldstein, Adrenaline, the Inner World and the Scientific Integrative Medicine

SHORT FEATURES and FACES ARTICLE Dr. Goldstein founded and directs the Clinical Neurocardiology Section at the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland. He is author of several books, including ‘Adrenaline and the Inner World: An Introduction to Scientific Integrative Medicine’, ‘Dysautonomias: A Handbook for Patients’, ‘Stress, Catecholamines, and […]

Stress-Induced Cardiomyopathy: Advance & Catecholamine-Induced Inflammation

Stress-Induced Cardiomyopathy: Advance & Catecholamine-Induced Inflammation

SHORT FEATURES and FACES ARTICLE A recent Editorial published in the March 2012 issue of Expert Review of Cardiovascular Therapy outlines some new insights and research trends related to stress-induced cardiomyopathy. Stress-induced cardiomyopathy, also known as “Takotsubo” cardiomyopathy, broken heart syndrome and apical ballooning syndrome, was first described in Japan, in 1990, by Sato et […]

First Evidence That Stress and Epinephrine Promote Leukemia Progression

First Evidence That Stress and Epinephrine Promote Leukemia Progression

In a recent PLoS One study, perhaps the first in the area of hematological tumors, and specifically leukemia, Shelly Inbar and colleagues from the Neuroimmunology Research Unit, Department of Psychology, Tel Aviv University, Israel, demonstrate marked adverse effects of stress hormones and prostaglandin E2 (PGE2) on survival rates of leukemic animals. An increasing body of […]

Bungee Jumping Related Stress Response May Suppress Innate Immunity Through the Activation of a Noncanonical Glucocorticoid Signaling Pathway

Bungee Jumping Related Stress Response May Suppress Innate Immunity Through the Activation of a Noncanonical Glucocorticoid Signaling Pathway

In this study, David van Westerloo and colleagues from the University of Amsterdam report that bungee jumping resulted in a time-dependent increase in the plasma concentrations of epinephrine, norepinephrine and cortisol; decreased whole blood production of TNF-alpha and IL-8, and a substantial reduction of bacterial phagocytosis by granulocytes and monocytes. Bungee jumping may represent an […]

Priming of Murine Bone Marrow-Derived Dendritic Cells with Epinephrine Favors the Induction of a Dominant Th2/Th17 Phenotype

Priming of Murine Bone Marrow-Derived Dendritic Cells with Epinephrine Favors the Induction of a Dominant Th2/Th17 Phenotype

A new study published in the journal Brain, Behavior, and Immunity indicates that the stress hormone epinephrine (also known as adrenaline) is able to drive a Th2/Th17-shift in dendritic cells (DCs) in the presence of a pathogenic stimulus. Dendritic cells cytokine and chemokine profiles are able to shape CD4+ T cell pathways and phenotypes and […]

Epinephrine and Mobilization of Cytotoxic Leukocytes

Epinephrine and Mobilization of Cytotoxic Leukocytes

A new Journal of Immunology study suggests that during acute stress the hormone epinephrine (adrenaline) is rapidly causing demargination of cytotoxic effector leukocytes from the marginal pool of blood vessels, thus releasing these cells into the circulation, which, in turn, may provide immediate protection from invading pathogens. Acute stress in humans is known to cause […]

Autonomic Nervous System Control of Leukocyte Distribution: Physiology and Implications for Common Human Diseases

Autonomic Nervous System Control of Leukocyte Distribution: Physiology and Implications for Common Human Diseases

Overview article Leukocytes are key components of the body’s defense system and the major subsets of leukocytes are granulocytes and lymphocytes. We and others have found that the distribution of these subsets are under the regulation of the autonomic nervous system. Of note, granulocytes express adrenergic receptors and the number and proportion of granulocytes increase […]

The Discovery of Adrenaline

The Discovery of Adrenaline

Historical Perspectives The first practical discovery of adrenaline by man occurred when one of our ancestral hominids while out for a stroll was unexpectedly surprised by a sabre-toothed tiger. Isolating and naming the compound were not uppermost in our man’s mind at the time and it was not until the late nineteenth century that progress […]

Mental State and Tuberculosis – Tohru Ishigami, 1918

Mental State and Tuberculosis – Tohru Ishigami, 1918

Historical Perspectives Tohru Ishigami was born in 1857, in the midst of a tempestuous period in Japanese history. The American fleet led by commodore Perry had arrived in Yokohama in 1853, and Japan slowly began to veer away from its isolationist policies, opening up to a flood of Western influence in various arenas. Importantly, transfer […]