Neurobiology of Cytokines – Part A and B

Neurobiology cytokines Part AThe term ‘cytokine’ originates from the combination of the Greek ‘cyto’, meaning cell, and ‘kinos’ meaning movement. Cytokines are proteins that aid cell to cell communication, typically in immune responses, exerting important regulatory functions in both innate and adaptive immune responses, and the traffic of immune cells towards sites of inflammation, infection and trauma.

The cytokines include the interleukins, lymphokines and cell signal molecules, such as tumor necrosis factor and the interferons, which trigger inflammation and respond to infections.

Evidence accumulated over the last 2-3 decades suggests that cytokines affect the central nervous system, regulate temperature and sleep, and participate in the pathogenesis of chronic and neuropathic pain, and depression or anxiety.

The Neurobiology of Cytokines, Part A includes recent evidence indicating the critical role for cytokines in the regulation of brain and endocrine function. This Volume 17 provides an overview of the effects of cytokines in the brain and on the endocrine system.

Topics covered include: general aspects of cytokines, including the endogenous agonists and antagonists, their receptors, their second messengers, and transport mechanisms for cytokines across the blood brain barrier; the anatomical localization of cytokines, cytokine receptors and their respective mRNA in brain and in endocrine tissues; methods for evaluating the in vivo and in vitro actions of cytokines on hormone secretion.

Publisher: Academic Press (August 1993)
Editor: Errol B. De Souza
ISBN-13: 978-0121852818
ISBN-10: 0121852814

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Neurobiology cytokines Part BNeurobiology of Cytokines, Part B: 17 (Methods in Neurosciences)

The Neurobiology of Cytokines, Part B: includes methods presented for easy adaptation to new systems and comprehensive protocols included for: The synthesis and release of cytokines; the study of their central nervous system actions; Studying the role of cytokines in human neuropathological conditions.

Publisher: Academic Press (October 22, 2013)
Editor: Errol B. De Souza
Print Length: 295 pages
ISBN-13: 978-0121852832
ISBN-10: 0121852830

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