What’s Hot

What’s hot covering significant new developments in neuroendocrine-immunology, neuroscience and immunology

Sarcopenia, the Skeletal Muscle as an Endocrine Organ and Aging

Sarcopenia, the Skeletal Muscle as an Endocrine Organ and Aging

In a recent review, Drs. A. Pratesi, F. Tarantini and M. Di Bari discuss major hormonal and immune mechanisms that drive the age-related decline in muscle quantity and quality. Besides the hormonal factors, the authors outline the role of some skeletal muscles mediators, termed ‘myokines’ that act in an autocrine, paracrine, or ‘hormone-like’ fashion. This […]

Neuroendocrine Immunology of Rheumatic Diseases: A 10-Year Update

Neuroendocrine Immunology of Rheumatic Diseases: A 10-Year Update

In 2001, Drs. Rainer Straub and Maurizio Cutolo, established experts in the field of neuroendocrine immunology of autoimmune and rheumatic diseases, published a large overview on the role of diverse neural and hormonal factors in rheumatoid arthritis. In the last decade, Maurizio Cutolo, president of the European League against Rheumatism (EULAR) has also organized the […]

Leptin Induces Th17 Responses: Relevance to Systemic Lupus Erythematosus

Leptin Induces Th17 Responses: Relevance to Systemic Lupus Erythematosus

A new Cutting Edge article, in the April 2013 issue of the Journal of Immunology, identifies a link between leptin and T helper (Th)17 cells, based on the evidence that leptin was able to promote Th17 responses in human CD4+ T cells and in mice, both in vitro and in vivo, by inducing the transcription […]

Adiponectin potentiates Th1 and Th17 immune responses

Adiponectin potentiates Th1 and Th17 immune responses

A new study published in March 2013 issue of the Journal of Immunology identifies a new immunomodulatory effect of adiponectin (APN) – its ability to activate DCs through PLCγ/JNK/NF-κB-signaling pathways and release of proinflammatory cytokines, and to potentiate Th1 and Th17 immune responses. Adiponectin, the most abundant adipokine, is known for its insulin-sensitizing effects, is […]

Cold-Induced Stress May Promote Chlamydia Genital Infection

Cold-Induced Stress May Promote Chlamydia Genital Infection

A recent study by Tesfaye Belay and Anthony Woart from the School of Arts and Sciences, Bluefield State College, Bluefield, WV, is perhaps the first to document a link between cold (weather) stress and the course of Chlamydia trachomatis infection. This common sexually transmitted infection is known to cause severe complications such as pelvic inflammatory […]

Activation of Beta2-Adrenoreceptors Drives T Helper Cell Priming In Favor of IL-17 Responses

Activation of Beta2-Adrenoreceptors Drives T Helper Cell Priming In Favor of IL-17 Responses

In a recent study published in the journal Cytokine, Michela Manni, Richard Granstein and Georges Maestroni, from the Center for Experimental Pathology, Locarno, Switzerland, provide new evidence suggesting that catecholamines, through activation of beta2-adrenoreceptors (ARs) on immune cells, may drive, in certain conditions, Th17 immune responses. The authors report that the beta2-AR agonist salbutamol is […]

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