Stress Immune Link

chapters on stress and immunity interactions and their impact on health and disease

Stress & Organ Specific Autoimmunity: A Complex Interrelationship

Stress & Organ Specific Autoimmunity: A Complex Interrelationship

OVERVIEW ARTICLE The evidence for stress contributing to the onset and course of autoimmune disease is circumstantial and the mechanisms by which stress affects autoimmune disease remain poorly understood. The best evidence for an effect of stress on the development of an autoimmune disorder is the well-known relationship between the clinical onset of Graves’ hyperthyroidism, […]

Psychosocial Stress and Chronic Viral Hepatitis

Psychosocial Stress and Chronic Viral Hepatitis

OVERVIEW ARTICLE Psychological stress is defined as a “state in which homeostasis is actually threatened or perceived to be so”, whereas homeostasis represents the complex and dynamic equilibrium between all systems functioning in a living organism [1, 2]. The above definition and context excludes psychiatric disorders that may impair the integrative capacities of the individual. […]

Stress and Cancer: A Link Through the Chinese Cultural Revolution

Stress and Cancer: A Link Through the Chinese Cultural Revolution

OVERVIEW ARTICLE It is now well recognized that preventive health care requires going beyond the immediate causes of diseases and understanding their fundamental socio-economic determinants. Cancer is one of these diseases that has emerged as the top killer, both physically and economically, surpassing heart disease, in many high-income countries. Does stress contribute to these increasing […]

The Link Between Stress, Emotions and Cytokine-Related Diseases

The Link Between Stress, Emotions and Cytokine-Related Diseases

OVERVIEW ARTICLE Adaptation is one of the core characteristics of living organisms, wherever it refers to proximate adjustments at individual level to inner or outer events, or to ultimate evolutionary processes at species-level. Biology and medicine have for a long time considered the non-specific symptoms of sickness (i.e. drowsiness, hypophagia, curled-up posture, fever) as signs […]

Pro- and Anti-Inflammatory Effects of Stress in the Brain: Mechanisms and Implications

Pro- and Anti-Inflammatory Effects of Stress in the Brain: Mechanisms and Implications

OVERVIEW ARTICLE Some stress protocols show a pro-inflammatory response in the brain and other systems characterized by a complex release of several inflammatory mediators such as cytokines, transcription factors, prostanoids and free radicals. Such response might contribute to cell damage during several neuropsychiatric diseases related with stress (post-traumatic stress disorder, major depressive disorder, anxiety disorders, […]

Stress, Proinflammation, Autoregulation and Cardiovascular Diseases

Stress, Proinflammation, Autoregulation and Cardiovascular Diseases

OVERVIEW ARTICLE Chronic stress can be an extremely detrimental phenomenon because it maintains an artificial state of excitation, whereas acute stress ends this process in a more timely manner. Therefore, it is not surprising to find proinflammatory phenomena occurring during chronic stress since the system maintains excitability, including that of immune origin. The cardiovascular system […]

Stress Response in Childhood Asthma

Stress Response in Childhood Asthma

OVERVIEW ARTICLE Accumulated evidence from animal models suggests that exogenously applied stress enhances airway reactivity and increases airway inflammation. This is considered to be the result of their inability to increase glucocorticoid production in response to stress to suppress the immune reaction. Clinical observations that stressful life events in asthmatic subjects increase the risk of […]