Stress-Immune News

reports on new advances in the area of stress-immunity interactions

Glucocorticoid Receptor Resistance Linked to Inflammation and Increased Disease Risk

Glucocorticoid Receptor Resistance Linked to Inflammation and Increased Disease Risk

A new Proceedings of the National Academy of Sciences of the USA (PNAS) study suggests that prolonged stress results in glucocorticoid receptor resistance (GCR), which results in a dysfunctional stress-immunity interaction, and, in turn, interferes with appropriate regulation of inflammation. The hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic-adrenomedullary system are the two major peripheral components of […]

A Mechanism Linking Immune Cells Activities, Biomarkers and Hippocampal Volume Loss to Post-Traumatic Stress Disorder

A Mechanism Linking Immune Cells Activities, Biomarkers and Hippocampal Volume Loss to Post-Traumatic Stress Disorder

In a recent review in Journal of Neurochemistry, James Andrews and Kameran Neises from the Naval Health Research Center, San Diego, California provide up to date information, and a brief but comprehensive overview on how peripheral blood mononuclear cells (PBMCs) and biomarkers may play a role in a putative mechanism and effective diagnosis of PTSD. […]

Negative and Competitive Interpersonal Stressors Linked to High Proinflammatory Cytokine Responses

Negative and Competitive Interpersonal Stressors Linked to High Proinflammatory Cytokine Responses

In a recent PNAS study, Jessica Chiang and colleagues from the Department of Psychology, David Geffen School of Medicine, University of California, Los Angeles, investigated the potential importance of negative, competitive and positive daily interactions on inflammatory activity. The authors of this study demonstrate that negative social interactions significantly predicted higher baseline levels of sTNFaRII […]

Functional Polymorphism in the 5HTR2C Gene Linked to Enhanced Stress-Induced Cortisol Response

Functional Polymorphism in the 5HTR2C Gene Linked to Enhanced Stress-Induced Cortisol Response

A study published in the journal Biological Psychiatry indicates that functional polymorphism in the 5HTR2C gene may contribute to altered stress reactivity, and to a specific endophenotype that may be linked to an increased risk of cardiovascular disease and type-2 diabetes. Enhanced hypothalamic–pituitary–adrenal (HPA) axis and cortisol responses to stress have been linked to high […]

Stress May Restrain the Immunostimulatory Effects of Interleukin-12

Stress May Restrain the Immunostimulatory Effects of Interleukin-12

A new study published in the journal Brain, Behavior, and Immunity suggests that chronic stress exposure can abolish the effects of immunostimulatory treatments such as the administration of interleukin (IL)-12, which is independent from the stress effects on baseline immune measures. Type 1 T-helper (Th)1 and proinflammatory cytokines are major activators of Th1-dependent cellular immunity, […]

Pathways by Which Stress May Affect Pregnancy Outcomes, Maternal Health and Fetal Development

Pathways by Which Stress May Affect Pregnancy Outcomes, Maternal Health and Fetal Development

In a recent review article in the journal Neuroscience & Biobehavioral Reviews, Lisa Christian discusses some biological mechanisms linking stress with maternal health, pregnancy outcomes and fetal development, focusing on peripheral immune markers, and stress reactivity and inflammatory processes during pregnancy Preterm delivery affects 12–13% of birth in the US, versus 5–9% in other developed […]

First Evidence That Stress and Epinephrine Promote Leukemia Progression

First Evidence That Stress and Epinephrine Promote Leukemia Progression

In a recent PLoS One study, perhaps the first in the area of hematological tumors, and specifically leukemia, Shelly Inbar and colleagues from the Neuroimmunology Research Unit, Department of Psychology, Tel Aviv University, Israel, demonstrate marked adverse effects of stress hormones and prostaglandin E2 (PGE2) on survival rates of leukemic animals. An increasing body of […]

Psychological Stress and Cardiovascular Diseases: Overview of Clinical & Epidemiological Data

Psychological Stress and Cardiovascular Diseases: Overview of Clinical & Epidemiological Data

In a review published in Postgraduate Medicine, Arthur Menezes and colleagues from the John Ochsner Heart and Vascular Institute, New Orleans, provide a comprehensive overview of the growing pool of clinical and epidemiological data concerning the association between psychological stress and cardiovascular disease, as well as the impact of cardiac rehabilitation and exercise therapy on […]

Psychological Stress, Immunoregulatory Balance and Human Inflammatory Diseases

Psychological Stress, Immunoregulatory Balance and Human Inflammatory Diseases

In this recent review, Gailen Marshall from the University of Mississippi Medical Center provides a brief but comprehensive overview of the major immune mechanisms affected by stress, and the relationships linking stress with various inflammatory diseases. According to Dr. Marshall, recent data indicates that immunoregulatory dysfunctions may play a more central role in stress-induced immune […]

Bungee Jumping Related Stress Response May Suppress Innate Immunity Through the Activation of a Noncanonical Glucocorticoid Signaling Pathway

Bungee Jumping Related Stress Response May Suppress Innate Immunity Through the Activation of a Noncanonical Glucocorticoid Signaling Pathway

In this study, David van Westerloo and colleagues from the University of Amsterdam report that bungee jumping resulted in a time-dependent increase in the plasma concentrations of epinephrine, norepinephrine and cortisol; decreased whole blood production of TNF-alpha and IL-8, and a substantial reduction of bacterial phagocytosis by granulocytes and monocytes. Bungee jumping may represent an […]

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