Stress-Immune News

Stress-Immune News reports on new advances in the area of stress-immune interactions

Combat-training stress and high pro-inflammatory markers in soldiers linked to increased intestinal permeability and gastrointestinal symptoms

Combat-training stress and high pro-inflammatory markers in soldiers linked to increased intestinal permeability and gastrointestinal symptoms

A study published in the February 2013 issue of Alimentary Pharmacology and Therapeutics reports that soldiers participating in as little as 6 weeks of combat training had high stress; anxiety and depression levels combined with gastrointestinal (GI) symptoms, pro-inflammatory immune activation and increased intestinal permeability. Gastrointestinal symptoms in soldiers are among the most common causes […]

The Role of Immunoregulating Microbes in Stress Resilience

The Role of Immunoregulating Microbes in Stress Resilience

In the March 2013 issue of Evolution, Medicine, and Public Health, Graham Rook et al. review a multitude of epidemiological data to highlight links between sanitation, psychiatric disorders and stress resilience. At the core of this concept is the Hygiene Hypothesis and “Old Friends” mechanism, which suggest that increased sanitation accounts for increases in inflammatory […]

Prenatal Immune Challenge – ‘Disease Primer’ Increasing the Offspring’s Vulnerability to Stress

Prenatal Immune Challenge – ‘Disease Primer’ Increasing the Offspring’s Vulnerability to Stress

A recent study published in Science is probably the first to provide evidence suggesting that prenatal immune challenge can function as a “disease primer” that amplifies the offspring’s susceptibility to stress and its detrimental neuro-pathological effects in peri-pubertal life. Epidemiologic studies indicate that prenatal infection may play an important role in the etiopathogenesis of schizophrenia, […]

Stress promotes tumor growth by amplifying the cancer cells’ ability to evade apoptosis

Stress promotes tumor growth by amplifying the cancer cells’ ability to evade apoptosis

A study published in the Journal of Clinical Investigation indicates that stress or the stress hormone adrenaline, through stimulation of beta-adrenoreceptors (ADRs), activate signaling pathways that lead to the inhibition of apoptosis. This enables prostate cancer cells to evade apoptosis, which is an important feature of tumor growth and metastasis. An increasing body of evidence […]

Neurotensin, CRH and Mast Cell Activation: Implications for Stress-Induced Exacerbations of Allergic Diseases

Neurotensin, CRH and Mast Cell Activation: Implications for Stress-Induced Exacerbations of Allergic Diseases

A study published in PLoS One indicates the presence of distinctive interactions between neurotensin (NT), corticotropin-releasing hormone (CRH) and mast cells that may be involved in inflammatory- and/or stress-related diseases. Psychological stress is known to aggravate asthma, migraines and certain autoimmune/inflammatory diseases. Although the mechanisms of stress-induced exacerbations of these conditions are not fully understood, […]

Maternal Stress, Neuropeptide Y System and the Offspring’s Vulnerability to Obesity and Metabolic Syndrome

Maternal Stress, Neuropeptide Y System and the Offspring’s Vulnerability to Obesity and Metabolic Syndrome

A recent report in the FASEB Journal indicates that Neuropeptide Y (NPY) system is a potential mediator of programming for the offspring’s vulnerability to obesity and metabolic syndrome induced by maternal low-protein diet (LPD). According to CDC more than one-third of U.S. adults (35.7%) are obese. As stated by Ogden C. et al., 17.1% of […]

Psychological Distress Is Dose-Dependently Related to Increased Mortality

Psychological Distress Is Dose-Dependently Related to Increased Mortality

A recent study published in the 2012 July issue of the British Medical Journal is probably the largest so far to show that a dose-response association exists between psychological distress and major causes of mortality across the full range of distress. Psychological stress has been linked to the development and progression of several common human […]

First Evidence That Psychological Stress Alters Levels Of Suppressor Cells in Breast Cancer

First Evidence That Psychological Stress Alters Levels Of Suppressor Cells in Breast Cancer

A new study in Cellular Immunology is perhaps the first to specifically measure levels of myeloid-derived suppressor cells (MDSC) in post operative breast cancer patients who were considered to be macroscopically disease-free. In this study, Bethany Mundy-Bosse and colleagues from the Department of Integrated Biomedical Sciences, the Ohio State University, Columbus OH investigated the association […]

Effect of Catecholamines on Bacterial Growth: New Mechanism of Stress Influencing Digestive Health and Disease

Effect of Catecholamines on Bacterial Growth: New Mechanism of Stress Influencing Digestive Health and Disease

In a contemporary review, published in Cell and Tissue Research, Mark Lyte, Lucy Vulchanova and David Brown provide a brief but comprehensive overview of the actions of stress mediators, especially CAs, on enteric luminal bacteria, on gut mucosal interactions with bacteria, and on brain–gut interactions initiated by or influencing enteric bacteria. The autonomic nervous system […]

Biobehavioral Factors, Stress and Cancer Progression: A Contemporary Review

Biobehavioral Factors, Stress and Cancer Progression: A Contemporary Review

In two recent reviews, published in 2011, Erin Costanzo, Anil Sood and Susan Lutgendorf provide a contemporary overview of the major pathways involved in the cross-talk between behavioral factors and the immune system that contribute to cancer development  and progression. The idea that psychological factors may contribute to cancer development and progression is not new. […]

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